NOVEL TOPICAL ANTI-AGING HERBAL COMPOSITION
Keywords:Anti-agin, Bakuchiol, Celosia, In silico, Polyherbal, Sea buckthorn
Objective: Anti-aging formulations are among the premier skin care products in the global market that are in huge demand. Different treatments are available to slow down skin aging, but are very expensive and are often found to produce adverse reactions to the skin in prolong use. Hence, present study has been designed to formulate poly herbal anti-aging skin care products and their evaluation thereon.
Methods: Anti-aging herbal skin care cream, gel and serum were prepared using two medicinal plants Hippophae salicifolia and Celosia argentea along with three bioactives caffeine, rutin and bakuchiol. The formulations were evaluated for physicochemical parameters like pH, texture analysis, acid value, short-term stability study, etc. Phenolics and flavanoid content were determined. Anti-aging potential was gauged by in silico studies using the glide tool of ‘Schrodinger’.
Results: Cream, gel and serum showed good physical appearance and were free from gritty particles and with smooth texture. Accelerated stability studies indicated insignificant changes in physicochemical parameters of the formulations. Based on the docking score and interaction with amino acid, compounds present in the plant extracts and bioactive showed good anti-aging activity.
Conclusion: The prepared herbal anti-aging formulations were found to be stable and exhibited good potential as an anti-aging combination. So, they can be used as an effective combination to protect skin from aging.
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