DESIGN AND EVALUATION OF FAST DISSOLVING TABLETS OF ERGOTAMINE TARTARATE


D. Nagendrakumar, Keshavshetti G G, Pratibha Mogale, Nanda Bhalke

Abstract


Objective: The main objective of this study was to formulate and evaluate the fast dissolving tablets of ergotamine tartarate with synthetic superdisintegrants.

Methods: Various formulations were prepared by direct compression method using different concentrations of crospovidone (12.5%-62.5%) and croscarmallose sodium (12.5%-62.5%) as superdisintegrants. Formulations were evaluated for precompressional parameters and postcompressional parameters like uniformity of weight, thickness, hardness, friability, drug content, wetting time, the water absorption ratio, in vitro disintegration time and in vitro dissolution study.

Results: Results revealed that among the 10 formulations, the formulation F5 containing 62.5% of crospovidone and formulation F10 containing 62.5% of croscarmallose sodium was found to be promising formulations. F5 shown disintegration time of 12 seconds and the drug release was up to 96% in 30 minutes and F10 shown disintegration time of 18 seconds and the drug release was up to 89% in 30 minutes.

Keywords: Ergotamine tartarate, Crospovidone, Croscarmallose sodium, Fast dissolving drug delivery.

Conclusion: From the result obtained, it can be concluded that formulation of fast dissolving tablet using crospovidone as a superdisintegrant showed improved disintegration and solubility and hence better patient compliance

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About this article

Title

DESIGN AND EVALUATION OF FAST DISSOLVING TABLETS OF ERGOTAMINE TARTARATE

Date

10-04-2015

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 2, 2015 Page: 101-104

Online ISSN

0975-7066

Statistics

201 Views | 181 Downloads

Authors & Affiliations

D. Nagendrakumar

Keshavshetti G G

Pratibha Mogale

Nanda Bhalke
College of Pharmacy, Humnabad 585330 (Karnataka)


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