DESIGN AND EVALUATION OF FORSKOLIN BUCCAL MUCOADHESIVE MICROSPHERES


Saritha T, Anna Balaji, Jaswanth. A

Abstract


Objective: The objective of the present study was to develop buccal mucoadhesive microspheres of Forskolin (FSK) for hypertension.

Methods: The microspheres were prepared by orifice ionic gelation method using different ratios of Sodium alginate and Kondagogu gum. Fourier-transformed infrared (FTIR) spectroscopy study shows that drug and other excipients are compatible with each other. A 22 full factorial design was applied to optimize the formulation considering concentration of Sodium alginate and Kondagogu gum as independent variables; % swelling index and In vitro % muco adhesion as dependent variables.

Results: The prepared formulations were characterized for % yield, drug entrapment efficiency, scanning electron microscopy (SEM) and in vitro drug release. Microspheres prepared with the ratio of sodium alginate: kondagogu gum (1:1.5) showed swelling index 37±3 % and in vitro mucoadhesion 73±3%. SEM images confirmed that microspheres are a hollow spherical structure to a smooth surface morphology. The drug entrapment efficacy of all the formulations was in the range of 58.42±1.2–79.52±1.5 %.

Conclusion: The values of coefficient correlation (r) were calculated and were found to be zero order release from prepared formulation (K2).

Keywords: Forskolin, Kondagogu gum, In vitro % muco adhesion, Swelling index.

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References


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About this article

Title

DESIGN AND EVALUATION OF FORSKOLIN BUCCAL MUCOADHESIVE MICROSPHERES

Date

15-07-2015

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 3, 2015 Page: 17-21

Online ISSN

0975-7066

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117 Views | 58 Downloads

Authors & Affiliations

Saritha T
Department of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana 500085, India, Department of Pharmaceutics, School of Pharmacy (Formerly Lalitha College of Pharmacy), Anurag Group of Institutions, Ghatkesar, Hyderabad 501301, Telangana, India,

Anna Balaji
Trinity College of Pharmaceutical Sciences, Karimnagar, Telangana, India

Jaswanth. A
Department of Pharmacology, Procadence Institute of Pharmaceutical Sciences, Medak, Telangana, India


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