EVALUATION OFANTI-OXIDANT AND ANTI-ACNE ACTIVITIES (IN-VITRO) OF THE FORMULATED HERBAL GELS

Khushbu Pravin Shah; Rashmi Shukla Srivastava

Khushbu Pravin Shah Mumbai Education Trustâ€™s Institute of Pharmacy, MET Complex, Bandra Reclamation, Bandra (W), Mumbai 400050, India
Rashmi Shukla Srivastava Mumbai Education Trustâ€™s Institute of Pharmacy, MET Complex, Bandra Reclamation, Bandra (W), Mumbai 400050, India

Abstract

Objective: The objective of the present study was to evaluate the anti-oxidant and anti-acne activities (in-vitro) of the formulated herbal gels.

Methods: Herbal extracts and volatile oils were prepared and procured. Preliminary screenings for the anti-oxidant and anti-acne activities (in-vitro) were carried out to select the suitable candidates for the preparation of anti-acne herbal gels. Gels were further evaluated for the activities.

Results: The herbal gel (F2) containing the herbal extracts (Azadirachtaindica, Ocmium sanctum, Curcuma longa) each (1%) and volatile oils (Melaleucaalternifoliae, Salviaesclareae and Citrus sinensis) each (0.05%) showed maximum anti-oxidant activity (IC₅₀ value 0.407 mg) amongst all four gels. Significant anti-acne activity against P. acne and S. epidermidis was showed by F2 when compared with the marketed synthetic gel (Clindac gel).

Conclusion: The study proves that the herbal actives used in the formulation have promising anti-oxidant and anti-acne activity.

Keywords: Herbal extracts, Volatile oils, Gelling agents, Anti-oxidant activity and anti-acne activity

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