EVALUATION OFANTI-OXIDANT AND ANTI-ACNE ACTIVITIES (IN-VITRO) OF THE FORMULATED HERBAL GELS

  • Khushbu Pravin Shah Mumbai Education Trust’s Institute of Pharmacy, MET Complex, Bandra Reclamation, Bandra (W), Mumbai 400050, India
  • Rashmi Shukla Srivastava Mumbai Education Trust’s Institute of Pharmacy, MET Complex, Bandra Reclamation, Bandra (W), Mumbai 400050, India

Abstract

Objective: The objective of the present study was to evaluate the anti-oxidant and anti-acne activities (in-vitro) of the formulated herbal gels.

Methods: Herbal extracts and volatile oils were prepared and procured. Preliminary screenings for the anti-oxidant and anti-acne activities (in-vitro) were carried out to select the suitable candidates for the preparation of anti-acne herbal gels. Gels were further evaluated for the activities.

Results: The herbal gel (F2) containing the herbal extracts (Azadirachtaindica, Ocmium sanctum, Curcuma longa) each (1%) and volatile oils (Melaleucaalternifoliae, Salviaesclareae and Citrus sinensis) each (0.05%) showed maximum anti-oxidant activity (IC50 value 0.407 mg) amongst all four gels. Significant anti-acne activity against P. acne and S. epidermidis was showed by F2 when compared with the marketed synthetic gel (Clindac gel).

Conclusion: The study proves that the herbal actives used in the formulation have promising anti-oxidant and anti-acne activity.

Keywords: Herbal extracts, Volatile oils, Gelling agents, Anti-oxidant activity and anti-acne activity.

References

1. Ray C, Trivedi P, Sharma V. Acne and its treatment lines. Int J Res Pharm Biosci 2013;3(1):1-16.
2. Vats A, Sharma P. Formulation and evaluation of topical anti acne formulation of coriander oil. Int J Pharm Pharm Sci Res 2012;2(3):61-6.
3. Daud SF, Pandey G, Joshi M, Pathak R, Wankhede SA. Study of antibacterial effect of some selected essential oils and medicinal herbs against acne causing bacteria. Int J Pharm Sci Invent 2013;2(1):27-34.
4. Kumar SM, Chandrasekar JN, Nanjan MJ. Herbal remedies for acne. Nat Prod Resour 2005;4(4):328-34.
5. NS, AT, NL. Anti-oxidant activity of Trigonella forneum graecum using various in vitro and ex vivo models. Int J Pharm Pharm Sci 2011;3(2):97.
6. Mistry K, Mehta M, Mendpara N, Gamit S, Shah G. Determination of antibacterial activity and MIC of crude extract of Abrusprecatorius L. Adv Biotech 2010;10(02):25-7.
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How to Cite
Shah, K., and R. Srivastava. “EVALUATION OFANTI-OXIDANT AND ANTI-ACNE ACTIVITIES (IN-VITRO) OF THE FORMULATED HERBAL GELS”. International Journal of Current Pharmaceutical Research, Vol. 7, no. 3, 1, pp. 47-50, https://innovareacademics.in/journals/index.php/ijcpr/article/view/7919.
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