SPECTROPHOTOMETRIC DETERMINATION OF MEPHEDRONE IN A BULK FORM
Objective: Two simple and sensitive Spectrophotometric methods are developed for estimation of Mephedrone.
Methods: The first method is based on oxidation of the drug with alkaline Potassium Permanganate at room temperature (25Â± Â°c). The increase in absorbance of colored Manganate ions was measured at 610 nm. The second method is based on the oxidation of the drug with 1, 10â€“phenanthroline producing red colored chromogen which is measured at 510 nm.
Results: All parameters affecting the developments of the color were investigated and the conditions were optimized. Under the optimum condition used, Beerâ€™s law was obeyed in the concentration range 40-160 Âµg/ml and 80-220 Âµg/ml for method A and B respectively. Molar absorptivity was found to be 4.60Ã—102 L. mole-1 cm-1and 3.89Ã—102 L. mole-1 cm-1 respectively.
Conclusion: The proposed methods are well suited for determination of Mephedrone in bulk samples.Keywords: Mephedrone, Spectophotomerty, Oxidation, Potassium permanganate, 1, 10-phenanthroline.
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