SPECTROPHOTOMETRIC DETERMINATION OF MEPHEDRONE IN A BULK FORM


Vaishali Parastekar, Vasant Barhate

Abstract


Objective: Two simple and sensitive Spectrophotometric methods are developed for estimation of Mephedrone.

Methods: The first method is based on oxidation of the drug with alkaline Potassium Permanganate at room temperature (25± °c). The increase in absorbance of colored Manganate ions was measured at 610 nm. The second method is based on the oxidation of the drug with 1, 10–phenanthroline producing red colored chromogen which is measured at 510 nm.

Results: All parameters affecting the developments of the color were investigated and the conditions were optimized. Under the optimum condition used, Beer’s law was obeyed in the concentration range 40-160 µg/ml and 80-220 µg/ml for method A and B respectively. Molar absorptivity was found to be 4.60×102 L. mole-1 cm-1and 3.89×102 L. mole-1 cm-1 respectively.

Conclusion: The proposed methods are well suited for determination of Mephedrone in bulk samples.

Keywords: Mephedrone, Spectophotomerty, Oxidation, Potassium permanganate, 1, 10-phenanthroline.

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About this article

Title

SPECTROPHOTOMETRIC DETERMINATION OF MEPHEDRONE IN A BULK FORM

Date

15-07-2015

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 7, Issue 3, 2015 Page: 51-55

Online ISSN

0975-7066

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115 Views | 251 Downloads

Authors & Affiliations

Vaishali Parastekar
V. E. S College of Arts, Science and Commerce, Sindhi Society, Chembur, Mumbai 400071

Vasant Barhate
V. E. S College of Arts, Science and Commerce, Sindhi Society, Chembur, Mumbai 400071


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