RECENT ADVANCES IN NANOCARRIER BASED THERAPEUTIC AND DIAGNOSTIC TOOLS FOR COLORECTAL CANCER
Colorectal cancer (CRC) is among the frequently diagnosed cancers and one of the leading causes of deaths in the world. It has remarkably high rates of metastasis, which incidentally is one of the leading causes of CRC related deaths. Ineffective drug concentration at the desired site of action and toxicity due to peripheral targeting limits the efficacy of the conventional chemotherapeutic treatments. Currently used traditional diagnostic tools have various shortcomings such as poor intracellular contrast between malignant and benign cells and low detection sensitivity in biological environment. Smarter drug delivery systems based on nano carriers have been proven remarkably promising in enhancing drug distribution and bioavailability, increasing half-life and achieving targeted drug delivery, thus, minimizing toxicity. Diagnosis employing nanoparticles is more effective in terms of stability, duration and efficiency. CRC targeting, both for drug delivery as well as diagnosis, is improved manifold by incorporating ligands of tumor specific surface receptors on the nanoparticles. Recently documented data have furnished cogent evidence apropos, the potential of active-targeted nanotherapeutics, and diagnostics in CRC therapy involving myriad forms of nanoparticles. This review deliberates the current status of nanocarriers, and the significance of their use in colorectal cancer therapy.
2. SJ Winawer. The multidisciplinary management of gastrointestinal cancer. Colorectal Cancer Screening Best Pract Res Clin Gastroenterol 2007;161:1031â€“48.
3. D Lin, S Feng, J Pan, Y Chen, J Lin, S Xie, et al. Chen, Colorectal cancer detection by gold nanoparticle based surface-enhanced raman spectroscopy of blood serum and statistical analysis. Opt Express 2011;19:1â€“8.
4. T Saphner, AC Wolff, GW Sledge, Wood WC, Davidson NE. Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults. N Engl J Med 2008;23:2191â€“200.
5. RJC Steele. Colorectal cancer screening. Br J Surg 2014;101:1338â€“40.
6. S Luo, E Zhang, Y Su, T Cheng, C Shi. A review of nir dyes in cancer targeting and imaging. Biomaterials 2011; 32:7127â€“38.
7. JK Roh, G Folprecht, P Ruff, C Stroh, S Tejpar, M Schlichting, et al. Rougier, Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. New Engl J Med 2009;360:1408â€“17.
8. MC de Jong, C Pulitano, D Ribero, J Strub, G Mentha, RD Schulick, et al. Pawlik, Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients. Ann Surg 2009;250:440â€“8.
9. H Ichihara, M Hino, M Umebayashi, Y Matsumoto, R Ueoka. Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo. Eur J Med Chem 2012;57:143â€“8.
10. D Mazhar, W Heller, J Stebbing. Recent advances in the systemic management of colorectal cancer. Future Oncol 2006;2:643-50.
11. L Feng, RJ Mumper. A critical review of lipid-based nanoparticles for taxane delivery. Cancer Lett 2013;334:157â€“75.
12. E Blanco, A Hsiao, AP Mann, MG Landry, F Meric-Bernstam, M Ferrari. Nanomedicine in cancer therapy: innovative trends and prospects. Cancer Sci 2011;102:1247â€“52.
13. C Yang, ZX Fu. Liposomal delivery and polyethylene-glycol liposomal oxaliplatin for the treatment of colorectal cancer (Review). Biomed Rep 2014;2(3):335â€“9.
14. H Maeda. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 2001;41:189â€“207.
15. KMG Lima, RF AraÃºjo, AA Araujo, A Luiza, CSL.Oliveira, LHS Gasparotto. Sensors and actuators bâ€¯: chemical. environmentally compatible bioconjugated gold nanoparticles as efficient contrast agents for colorectal cancer cell imaging. Sens Actuators B 2014;196:306â€“13.
16. T Tanaka. Recent advances in molecular targeted therapy for advanced colorectal cancer and nonâ€“small cell lung cancer. J Phys Chem Biophys 2012;2:108. doi: 10.4172/2161-0398.1000108. [Article in Press].
17. J Sudimack, RJ Lee. Targeted drug delivery via the folate receptor. Adv Drug Delivery Rev 2000;41:147â€“62.
18. R Khatik, P Dwivedi, VR Junnuthula, K Sharma, K Chuttani, AK Mishra, et al. Potential in vitro and in vivo colon specific anticancer activity in a HCT-116 xenograft nude mice modelâ€¯: targeted delivery using enteric coated folate modified nanoparticles. RSC Adv 2015;5:16507â€“20.
19. PS Low, AC Antony. Folate receptor-targeted drugs for cancer and inflammatory diseases. Adv Drug Delivery Rev 2004;56:1055â€“8.
20. JD Byrne, T Betancourt, L Brannon-Peppas. Active targeting schemes for nanoparticle systems in cancer therapeutics. Adv Drug Delivery Rev 2008;60:1615â€“26.
21. JJ Turek, CP Leamon, PS Low. Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells. J Cell Sci 1993;106:423â€“30.
22. Y Yamada, N Itano, H Narimatsu, T Kudo, S Hirohashi, A Ochiai, A Niimi, et al. Kimata, Receptor for Hyaluronan-Mediated motility and CD44 expressions in colon cancer assessed by quantitative analysis using real-time reverse transcriptase-polymerase chain reaction. Jpn J Cancer Res 1999;90:987â€“92.
23. M KÃ¶bel, W Weichert, K CrÃ¼well, WD Schmitt, C LautenschlÃ¤ger, S Hauptmann. Epithelial hyaluronic acid and CD44v6 are mutually involved in invasion of colorectal adenocarcinomas and linked to patient prognosis. Virchows Arch 2004;445:456â€“64.
24. KY Choi, EJ Jeon, HY Yoon, BS Lee, JH Na, KH Min, et al. Theranostic Nanoparticles based on PE Gylated hyaluronic acid for the diagnosis. Ther Monitoring Colon Cancer Biomater 2012;33:6186â€“93.
25. JP Tiernan, SL Perry, ET Verghese, NP West, S Yeluri, DG Jayne, et al. Hughes, Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. Br J Cancer 2013;108:662â€“7.
26. K Huang, J Chieh, I Lin, H Horng, H Yang, C Hong. Anti-CEA-functionalized superparamagnetic iron oxide nanoparticles for examining colorectal tumors in vivo. Nanoscale Res Lett 2013;8(1):413.
27. JP Tiernan, N Ingram, SL Perry, JV Rushworth, P Louise, PA Millner, et al. CEA-Targeted nanoparticles allow specific in vivo fluorescent imaging of colorectal cancer models. Nanomedicine 2015;10(8):1223-31.
28. P Jantscheff, L Terracciano, A Lowy, K Glatz-Krieger, F Grunert, B Micheel, et al. Rochlitz, Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. J Clin Oncol 2003;21:3638â€“46.
29. K Tachibana, S Hirota, H Iizasa. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 1998;393:591â€“4.
30. PA Ruffini, P Morandi, N Cabioglu. Manipulating the chemokine-chemokine receptor network to treat cancer. Cancer 2007;109:2392â€“404.
31. Z Liang, Y Yoon, J Votaw. Silencing of CXCR4 blocks breast cancer metastasis. Cancer Res 2005;65(3):967-71.
32. F Abedini, M Ismail, H Hosseinkhani, TAT Ibrahim, AR Omar. Effects of CXCR4 siRNA/Dextran-spermine nanoparticles on CXCR4 expression and serum LDH levels in a mouse model of colorectal cancer metastasis to the liver. Cancer Manage Res 2011;3:301â€“9.
33. N Nishida, H Yano, T Nishida, T Kamura, M Kojiro. Angiogenesis in cancer. Vasc Health Risk Manage 2006;2:213â€“9.
34. J Gong, D Wang, L Sun, E Zborowska, JKV Willson, MG Brattain. Role of Î±5Î²1 integrin in determining malignant properties of colon carcinoma cells. Cell Growth Differ 1997;8:83â€“90.
35. Aiyer JA Varner. Integrins in cancer progression and therapy. Sci Med 2005;10:84â€“96.
36. N Arber, B Levin. Chemoprevention of colorectal cancer: ready for routine use? Recent Results Cancer Res 2005;166:213â€“30.
37. RN Dubois. Review article: cyclooxygenase-a target for colon cancer prevention. Aliment Pharmacol Ther 2000;14:64â€“7.
38. S Ayakawa, Y Shibamoto, C Sugie, M Ito, H Ogino, N Tomita, et al. Sawa, Antitumor effects of a cyclooxygenase-2 inhibitor, meloxicam, alone and in combination with radiation and/or 5-fluorouracil in cultured tumor cells. Mol Med Rep 2009;2:621â€“5.
39. RE Harris, J Beebe-Donk, GA Alshafie. Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case controlled studies. Subcell Biochem 2007;42:193-212.
40. KM Hajra, ER Fearon. Cadherin and catenin alterations in human cancer. Genes Chromosomes Cancer 2002;34:255â€“68.
41. Porebska, A HarloziÅ„ska, T Bojarowski. Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2, ERB B3) in colorectal adenocarcinomas and adenomas. Tumour Biol 2000;21:105â€“15.
42. S Feng, J Lin, M Cheng, YZ Li, G Chen, Z Huang, et al. Gold nanoparticle based surface-enhanced raman scattering spectroscopy of cancerous and normal nasopharyngeal tissues under near-infrared laser excitation. Appl Spectrosc 2009;63:1089â€“94.
43. CH Su, HS Sheu, CY Lin, CC Huang, YW Lo, YC Pu, et al. Nanoshell magnetic resonance imaging contrast agents. J Am Chem Soc 2007;129:2139â€“46.
44. TJ Yoon, JS Kim, BG Kim, KN Yu, MH Cho, JK Lee. Multifunctional nanoparticles possessing a â€˜â€˜magnetic motor effectâ€ for drug or gene delivery. Angew Chem Int Ed Engl 2005;44:1068â€“71.
45. NI Goldstein, M Prewett, K Zuklys, P Rockwell, J Mendelsohn. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in human tumor xenograft model. Clin Cancer Res 1995;1:1311â€“8.
46. Y Cho, T Yoon, E Jang, K Soo, S Young, O Ran, C Park, Y Kim, et al. Chang, Cetuximab-Conjugated magneto-fluorescent silica nanoparticles for in vivo colon cancer targeting and imaging. Cancer Lett 2010;299:63â€“71.
47. Riley K. FDA: New warnings required on use of gadolinium-based contrast agents. U.S. Food and Drug Administration. 2010. Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm225286. htm [Last accessed on 21 Apr 2015].
48. MA Oghabian, N Gharehaghaji, S Amirmohseni, S Khoei, M Guiti. Detection sensitivity of lymph nodes of various sizes using USPIO nanoparticles in magnetic resonance imaging. Nanomed-Nanotechnol 2010;6:496â€“9.
49. S MÃ¼ller. Magnetic fluid hyperthermia therapy for malignant brain tumors an ethical discussion. Nanomed-Nanotechnol 2009;5387â€“93.
50. SJ Yang, FH Lin, KC Tsai, MF Wei, HM Tsai, JM Wong, et al. Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. Bioconjugate Chem 2010;21:679â€“89.
51. C Kennedy, RH Pottier, DC Ross. Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol 1990;6:143-8.
52. Feng RJ Mumper. A Critical review of lipid-based nanoparticles for taxane delivery. Cancer Lett 2013;334:157â€“75.
53. ErdoÇ§ YDP Limasale, D Keskin, A Tezcaner, S Banerjee. In vitro Characterization of a liposomal formulation of Celecoxib, Cholesterol, and Polyethylene glycol and its functional effects. J Pharm Sci 2013;102:3666â€“77.
54. Abu-Lila, T Suzuki, Y Doi, T Ishida, H Kiwada. Oxaliplatin targeting to angiogenic vessels by PE Gylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model. J Controlled Release 2009;134:18â€“25.
55. R Suzuki, T Takizawa, Y Kuwata, M Mutoh, N Ishiguro, N Utoguchi, et al. Effective anti-tumor activity of oxaliplatin encapsulated in transferrin-PEG-liposome. Int J Pharm 2008;346:143â€“50.
56. Pendyala PJ. Creaven, In vitro cytotoxicity, protein binding, red blood cell partitioning, and biotransformation of oxaliplatin. Cancer Res 1993;53:5970â€“6.
57. Yang, HZ Liu, ZX Fu, WD Lu. Oxaliplatin long-circulating liposomes improved therapeutic index of colorectal carcinoma. BMC Biotechnol 2011;11:21. DOI: 10.1186/1472-6750-11-21. [Article in Press].
58. Garg, AW Tisdale, E Haidari, E Kokkoli. Targeting colon cancer cells using PE Gylated liposomes modified with a fibronectin-mimetic peptide. Int J Pharm 2009;366:201â€“10.
59. Adil, L Belur, TR Pearce, RM Levine, AW Tisdale, BS Sorenson, et al. PR_b Functionalized stealth liposomes for targeted delivery to metastatic colon cancer. Biomater Sci 2013;1:393.
60. Chaszczewska-markowska, K Stebelska, A Sikorski, J Madej, A Opolski, M Ugorski. Liposomal formulation of 5-fluorocytosine in suicide gene therapy with cytosine deaminaseâ€“for colorectal cancer. Cancer Lett 2008;262:164â€“72.
61. Wang L. Gene therapy with recombinant adenovirus encoding endostatin encapsulated in cationic liposome in coxsackievirus and adenovirus receptor-deficient colon carcinoma murine models. Hum Gene Ther 2011;22:1061â€“9.
62. Hardiansyah, LY Huang, MC Yang, TY Liu, SC Tsai, CY Yang, et al. Magnetic liposomes for colorectal cancer cells therapy by high-frequency magnetic field treatment. Nanoscale Res Lett 2014;9(1):497.
63. KY Hidetsugu, GKU Ryuichi. Remarkable inhibitory effects of hybrid liposomes on growth of human colon cancer cells through induction of cell cycle arrest along with apoptosis. Int J Nanomed 2011;6:1913â€“20.
64. H Ichihara, M Hino, M Umebayashi, Y Matsumoto, R Ueoka. Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo. Eur J Med Chem 2012;57:143-8.
65. V Santini, A Gozzini, B Scappini, A Grossi, P Rossi Ferrini. Searching for the magic bullet against cancer: the butyrate saga. Leuk Lymphoma 2001;42:275-89.
66. Brioschi, GP Zara, S Calderoni, MR Gasco, A Mauro. Cholesterylbutyrate solid lipid nanoparticles as a butyric acid pro drug. Molecules 2008;13:230-54.
67. C Hollman, MB Katan. Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol 1999;37:937-42.
68. MR Vijayababu, P Kanagaraj, A Arunkumar, R Ilangovan, MM Aruldhas, J Arunakaran. Quercetin-induced growth inhibition and cell death in prostatic carcinoma cells (PC-3) are associated with an increase in p21 and hypophosphorylated retinoblastoma proteins expression. J Cancer Res Clin Oncol 2005;131:765-71.
69. KA Khaled, YM El-Sayed, BM Al-Hadiya. Disposition of the flavonoid quercetin in rats after single intravenous and oral doses. Drug Dev Ind Pharm 2003;29:397-403.
70. JG Geoghegan, J Scheele. Treatment of colorectal liver metastases. Br J Surg 1999;86:158-69.
71. M Del Vecchio, E Bajetta, S Canova, MT Lotze, A Wesa, G Parmiani, et al. Interleukin-12:biological properties and clinical application. Clin Cancer Res 2007;13:4677-85.
72. JP Leonard, ML Sherman, GL Fisher, LJ Buchanan, G Larsen, MB Atkins, et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 1997;90:2541-8.
73. Xu Q, L Guo, X Gu, B Zhang, X Hu, J Zhang, et al. Prevention of colorectal cancer liver metastasis by exploiting liver immunity via chitosan-TPP/nanoparticles formulated with IL-12. Biomaterials 2012;33:3909â€“18.
74. Venkatesan P, N Puvvada, R Dash, BN Prashanth Kumar, D Sarkar, B Azab, et al. The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer. Biomaterials 2011;32:3794â€“806.
75. Schiffmann, TJ Maier, I Wobst, A Janssen, H Corban-Wilhelm, C Angioni, et al. The anti-proliferative potency of celecoxib is not a class effect of coxibs. Biochem Pharmacol 2008;76:179â€“87.
76. HH Pham, P Luo, F Genin, AK Dash. Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying technique. AAPS Pharm Sci Tech 2002;3(1):1-9.
77. P Li, Y Wang, F Zeng, L Chen, Z Peng, LX Kong. Synthesis and characterization of folate conjugated chitosan and cellular uptake of its nanoparticles in HT-29 cells. Carbohydr Res 2011;346:801â€“6.
78. Jain, S. K. Jain, N. Ganesh, J. Barve, A. M. Beg, Design and Development of Ligand-Appended Polysaccharidic Nanoparticles for the Delivery of Oxaliplatin in Colorectal Cancer. Nanomedicine 2010;6(1):179â€“90.
79. M Urbanska, ED Karagiannis, G Guajardo, RS Langer, DG Anderson. Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer. Biomaterials 2012;33(18):4752-61.
80. L Leclere, P Van Cutsem, C Michiels. Anti-Cancer activities of pH-or heat-modified pectin. Front Pharmacol 2013;4:1â€“8.
81. MB Subudhi, A Jain, A Jain, P Hurkat, S Shilpi, A Gulbake, et al. Eudragit S100 coated citrus pectin nanoparticles for colon targeting of 5-Fluorouracil. Material 2015;8:832â€“49.
82. Q Hu, B Liang, Y Sun, X Guo, Y Bao, D Xie, et al. Preparation of bufalin-loaded pluronic polyetherimide nanoparticles, cellular uptake, distribution, and effect on colorectal cancer. Int J Nanomedicine 2014;9:4035â€“41.
83. Wang, M Zhao, YR Liu, X Luan, YY Guan, Q Lu, et al. Suppression of colorectal cancer subcutaneous xenograft and experimental lung metastasis using nanoparticle-mediated drug delivery to tumor neovasculature. Biomaterials 2014;35:1215â€“26.
84. M Tan, J Luo, Y Tian. Delivering curcumin and gemcitabine in one nanoparticle platform for colon cancer therapy. RSC Adv 2014;4:61948â€“59.
85. H Tersigni. Core-Excited nanoparticle thermotherapy (CENT) bound to targeting agents that deliver them tumor cell, US; 2012.
86. H Zhao, L Shi. Nanoparticle compositions for nucleic acids delivery system, U. S. Patent 20110111044; 2011.
87. Leuschner, CSSR Kumar, W Hansel, J Hormes. In vivo imaging and therapy with magnetic nanoparticle conjugates, US. Patent 20090169478; 2009.
88. Phase 1 Study of PLX7486 as Single Agent and With Gemcitabine Plus Nab-Paclitaxel in Patients With Advanced Solid Tumors. Available from: http://ClinicalTrials.gov/ show/NCT01804530 [Last accessed on 03 May 2015].
89. Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer. Available from: http://ClinicalTrials.gov/show/NCT02010567 [Last accessed on 03 May 2015].
90. Pharmacokinetic, Safety and Efficacy Study of Nanoparticle Paclitaxel in Patients With Peritoneal Cancers. Available from: http://ClinicalTrials.gov/show/NCT00666991 [Last accessed on 03 May 2015].
91. TKM 080301 for Primary or Secondary Liver Cancer. Available from: http://ClinicalTrials.gov/show/NCT01437007 [Last accessed on 03 May 2015].
92. Breath Testing for Breast and Colon Cancer Diagnosis-NaNose Study. Available from: http://ClinicalTrials.gov/ show/ NCT01292369 [Last accessed on 03 May 2015].