USE OF ALUMINA IN PREPARATION OF OXIME: A PRECURSOR FOR BECKMANN REARRANGEMENT
Keywords:Alumina, Beckmann Rearrangement, Column Chromatography, Ethanol, Hydroxylamine Hydrochloride, Oxime, Thin Layer Chromatography
Objective: Oxime is an important precursor for many reactions like Beckmann rearrangement, oxime ether preparation etc. Oxime is generally prepared in strong acidic , strong basic  medium. Even some methods involving mild basic medium  is also known. But these procedures involve hazardous chemicals like inorganic acid, inorganic base, organic bases like Pyridine , Hy amine  etc. Some green methodologies have been also developed but that also involves expensive reagents like Bi2O3  etc. Inthis context, this work has been carried out to develop a new methodology for oxime preparation.
Methods: Different oxims have been prepared in heating condition using water-ethanol medium and alumina as a base. Products have been isolated by column chromatography using 200 mesh silica gel followed by fractional crystallization. Products were verified by melting point analysis.
Results: Four different aromatic oxims have been prepared in excellent yield and in an economically viable condition.
Conclusion: Here preparation of oxime in a mild basic medium has been reported. Alumina (Al2O3) is pretty cheap and not mentionable hazardous and it has been used here for the first time in synthesis of oxime.
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