@article{S._Babu T._M._2017, title={EFFECT OF SHILAJIT ON EXPERIMENTAL MODELS OF INFLAMMATORY BOWEL DISEASE IN RATS}, volume={9}, url={https://journals.innovareacademics.in/index.php/ijcpr/article/view/20756}, DOI={10.22159/ijcpr.2017v9i4.20756}, abstractNote={<p class="Default"><strong>Objective: </strong>Inflammatory bowel disease (IBD) is a chronic condition of the intestine with unknown etiology involving multiple immunes, genetic and environmental factors. Oxidative stress is believed to be a key factor in the pathogenesis and perpetuation of the mucosal damage in IBD. The present study is to elucidate the effects of <em>shilajit </em>extract on the extent and severity of enterocolitis induced by subcutaneous administration of Indomethacin (7.5 mg/kg b. w) in Wistar rats.</p><p class="Default"><strong>Methods: </strong>Study comprised of 6 groups (n=6), normal vehicle control, indomethacin-induced (7.5 mg/kg, 2days), <em>shilajit </em>alone 50 mg/kg b. w, <em>shilajit </em>treated groups (25 and 50 mg/kg, p. o) and sulfasalazine treated (100 mg/kg, p. o) groups. Drug treatment continued for 11 d and on 12<sup>th</sup> d scarification was done. The colonic mucosal injury was assessed by macroscopic scoring, biochemical (LDH, MPO, GSH and LPO) tests were performed.</p><p class="Default"><strong>Results: </strong>Pretreatment with <em>shilajit </em>showed a decrease in macroscopic scores, LDH, MPO, LPO and elevation levels of GSH as compared to the indomethacin-treated group.</p><p class="Default"><strong>Conclusion: </strong>The present study suggests that the protective effect of <em>shilajit </em>in indomethacin-induced enterocolitis might be attributed to its scavenging effect on oxygen-derived free radicals and may be beneficial in patients with inflammatory bowel disease.</p>}, number={4}, journal={International Journal of Current Pharmaceutical Research}, author={S., Neelima and Babu T., Naresh and M., Pradeep Kumar}, year={2017}, month={Jul.}, pages={35–37} }