@article{Das_Chakraborty_Dash_2017, title={BIOEQUIVALENCE STUDY OF ANTIDIABETIC ACTIVITY BETWEEN TWO MARKETED FORMULATIONS OF METFORMIN ON GLUCOCORTICOID-INDUCED HYPERGLYCEMIA IN RABBIT}, volume={9}, url={https://journals.innovareacademics.in/index.php/ijcpr/article/view/20762}, DOI={10.22159/ijcpr.2017v9i4.20762}, abstractNote={<p><strong>Objective: </strong>Bioequivalence studies are the commonly accepted methods displaying therapeutic equivalence between two products. This study was conducted to evaluate the bioequivalence study of anti-diabetic activity between two formulations of metformin tablets which were marketed in India.</p><p><strong>Methods: </strong>In <em>in vitro</em> study five essential <em>in vitro</em> tests including disintegration, weight variation, hardness, friability and a comparative <em>in vitro</em> dissolution study were performed.</p><p><strong>Results: </strong>For <em>in vivo</em> study adult male rabbits were divided into three groups of two each. The first group is regarded as control group received 3 ml of normal saline daily by using the gastric tube for 15 d and the second and third group received (0.35 mg/Kg B.W. single dosage) of dexamethasone tablets which were powdered, dissolved in 3 ml of normal saline daily for 15 d. After 15 d the blood glucose of second and third group was estimated and after that received formulation X and formulation Y, dissolved in 3 ml of normal saline daily for 15 d at the dose of 0.5 gm/kg body weight orally. After 15 d again blood glucose of second and third group was estimated and compare the results of both the group. This shows the favourable response of metformin against glucocorticoid-induced renal damage and hyperglycemia.</p><p><strong>Conclusion: </strong>Results of this study showed that the extent, rate of absorption and anti-diabetic activity of two different formulations of metformin tablets are bioequivalent to each other.</p>}, number={4}, journal={International Journal of Current Pharmaceutical Research}, author={Das, Debanga and Chakraborty, Jashabir and Dash, Suvakanta}, year={2017}, month={Jul.}, pages={47–50} }