@article{Examinati_Wulandari_Putri Huspa_Andayaningsih_2018, title={CYTOTOXICITY OF AROMATIC COMPOUND FROM AN ENDOPHYTIC FUNGUS, CLADOSPORIUM SP. EN-S01}, volume={10}, url={https://journals.innovareacademics.in/index.php/ijcpr/article/view/30964}, DOI={10.22159/ijcpr.2018v10i6.30964}, abstractNote={<p><strong>Objective: </strong>Endophytes have the potential to synthesize various bioactive secondary metabolites. The aims of the study were to isolate the major compound from endophytic <em>Cladosporium</em> sp. EN-S01., identify its function group, then evaluate its cytotoxicity.<strong></strong></p><p><strong>Methods: </strong>The endophytic fungus was grown in potato dextrose broth and extracted using ethyl acetate. Secondary metabolites were isolated by chromatographic separation and re-crystallization, and function group was determined by infrared spectroscopy<em>. In vitro </em>cytotoxicity was evaluated by the prestoblue assay.</p><p><strong>Result: </strong>The isolated aromatic compound evaluated by prestoblue assay against breast cancer cell line MCF-7 showed cytotoxicity with IC<sub>50</sub> value of 746,03 ppm.</p><p><strong>Conclusion</strong>:<strong> </strong>Our findings indicate this aromatic compound might be useful lead compounds to develop cytotoxic drugs.</p>}, number={6}, journal={International Journal of Current Pharmaceutical Research}, author={Examinati, R. R. Indry Noviarin and Wulandari, Asri Peni and Putri Huspa, Desi Harneti and Andayaningsih, Poniah}, year={2018}, month={Nov.}, pages={10–12} }