@article{S._S._2018, title={EVALUATION OF ANTI-ASTHMATIC ACTIVITY OF METHANOLIC EXTRACT OF BERLERIA PRIONITIS LINN. AERIAL PARTS}, volume={10}, url={https://journals.innovareacademics.in/index.php/ijcpr/article/view/30971}, DOI={10.22159/ijcpr.2018v10i6.30971}, abstractNote={<p><strong>Objective: </strong>The aim of the present study is to evaluate the aerial parts of a plant of <em>Barleria prionitis </em>Linn., for its antiasthmatic activity with the separation of active moieties.</p><p><strong>Methods: </strong>Adult wistar albino rats were used for the anti-inflammatory study. Histamine-induced bronchospasm was conducted on isolated goat trachea.</p><p><strong>Results: </strong>The dried and powdered aerial parts of <em>Berleria prionitis</em> was extracted with continuous soxhlet extraction with Petroleum ether (40-60 ° C), Chloroform, Ethyl acetate, Acetone, Methanol, and Hydroalcoholic solvents. Preliminary phytochemical screening of all extracts was done. Preliminary animal studies by <em>In vitro</em> isolated goat trachea chain preparation of all extracts were done to find out the potent extract. In this study, the methanolic extract of aerial parts of <em>Berleria prionitis </em>was found to be potent comparative to another extract. The results of carrageenan induced rat paw oedema model indicated the dose-dependant anti-inflammatory activity. As compared to standard drug (Indomethacin), methanolic extract showed similar activity which was found to be statistically significant (P<0.0001). The extent of DPPH radical scavenging was determined by calculated the IC<strong><sub>50</sub></strong> value of methanolic extract <em>Berleria prionitis </em>(133.5) compared with the Ascorbic acid (114.7) taken as standard. In the present study, the histamine-induced dose-dependent contraction of goat tracheal chain was significantly inhibited (p<0.001) by methanolic extract of aerial parts of <em>Berleria prionitis</em> (200 μg/ml). Thus the present study revealed that the methanolic extract of <em>Berleria prionitis </em>(MEBP) has significant antihistaminic (H1 receptor antagonist) activity.</p><p><strong>Conclusion: </strong>In view the fact that tribal have well experienced the antiasthmatic effects of the roots of <em>Barleria prionitis </em>Linn. The results of our study, for the first time, show that the methanolic extract of aerial parts of Berleria prionitis Linn. possesses antioxidant, anti-inflammatory, Bronchodilator properties and therefore can be<strong> </strong>used for the antiasthmatic treatment.<strong></strong></p>}, number={6}, journal={International Journal of Current Pharmaceutical Research}, author={S., Manekar Snehal and S., Charde Manoj}, year={2018}, month={Nov.}, pages={30–34} }