@article{THORAT_SHEGAONKAR_KUMBHAR_MATOLE_HOSMANI_2020, title={SPECTROPHOTOMETRIC DETERMINATION OF DASATINIB IN PHARMACEUTICAL FORMULATIONS}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijcpr/article/view/37492}, DOI={10.22159/ijcpr.2020v12i2.37492}, abstractNote={<p><strong>Objective: </strong>A new, simple, sensitive, precise and reproducible bioanalytical method was developed for the determination of Dasatinib in pharmaceutical formulations with Chloranilic acid.</p> <p><strong>Methods: </strong>The method is based on formation of violet colored complex. The UV spectrum of Dasatinib in methanol showed λ max at 521 nm. Beer’s law is valid in the concentration range of 10-60 μg/ml. This method was validated for linearity, accuracy, precision, ruggedness and robustness.</p> <p><strong>Results: </strong>The method has demonstrated excellent linearity over the range of 10-60 μg/ml with regression equation y = 0.021x-0.083 and regression correlation coefficient r<sup>2</sup>= 0.997. Moreover, the method was found to be highly sensitive with LOD (2.96μg/ml) and LOQ (8.98μg/ml).</p> <p><strong>Conclusion: </strong>Based on results the proposed method can be successfully applied for the assay of Dasatinib in various pharmaceutical dosageforms.</p>}, number={2}, journal={International Journal of Current Pharmaceutical Research}, author={THORAT, YOGESH and SHEGAONKAR, ANITA and KUMBHAR, SMITA and MATOLE, VINOD and HOSMANI, AVINASH}, year={2020}, month={Mar.}, pages={68–71} }