@article{MADUR_MATOLE_KALSHETTI_2020, title={UV VISIBLE SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF DASATINIB IN BULK AND SOLID DOSAGE FORM}, volume={12}, url={https://journals.innovareacademics.in/index.php/ijcpr/article/view/39089}, DOI={10.22159/ijcpr.2020v12i4.39089}, abstractNote={<p><strong>Objective: </strong>A new, simple, sensitive, precise, reproducible UV visible spectrophotometric method was developed for the determination of Dasatinib in Tablet dosage form with­­­ methanol.</p> <p><strong>Methods: </strong>The method is based on the formation of a colorlesscomplex. The UV spectrum of Dasatinib in methanol showed maximum wavelength at 248 nm. Beer’s law is valid in the concentration range of 7-35µg/ml. this method was validated for linearity, accuracy, precision, assay, ruggedness and robustness.</p> <p><strong>Results: </strong>The method has demonstrated excellent linearity over the range of 7-35µg/ml with the regression equation y = 0.0332x+0.0633 and regression coefficient i.e. r<sup>2</sup>= 0.9994moreover, the method was found to be highly sensitive with LOD(1.08µg/ml) and LOQ(3.29µg/ml).</p> <p><strong>Conclusion: </strong>Based on the results the proposed method can be successfully applied for the assay of Dasatinib in various tablet dosage forms.</p>}, number={4}, journal={International Journal of Current Pharmaceutical Research}, author={MADUR, SAILI and MATOLE, VINOD and KALSHETTI, MALLINATH}, year={2020}, month={Jul.}, pages={90–93} }