TY - JOUR AU - Sireesha, P. AU - Kiranjyothi, R. PY - 2016/04/07 Y2 - 2024/03/29 TI - FORMULATION AND EVALUATION OF ANTIDEPRESSANT ORODISPERSIBLE TABLETS JF - International Journal of Current Pharmaceutical Research JA - Int J Curr Pharm Sci VL - 8 IS - 2 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijcpr/article/view/12097 SP - 52-60 AB - <p><strong>Objective: </strong>Orodispersible tablet formulation was proposed to be developed for fluoxetine hydrochloride taking into consideration it's physical, chemical, pharmacological and pharmacokinetic properties and was proposed to be investigated with respect to its potential to be developed into novel drug delivery system</p><p><strong>Methods: </strong>Carrying out pre-formulation studies such as drug-polymer interaction analysis by Fourier Transform Infrared (FTIR) spectroscopy and pre-compression characterization of a physical mixture of drug and excipients. Preparation of the orodispersible tablet by using various super disintegrants like croscarmellose, crospovidone &amp; sodium starch glycolate. Preparation of the orodispersible tablet by using various methods like wet granulation method &amp; sublimation method.</p><p><strong>Results: </strong>To evaluate tablets for various physicochemical parameters such as hardness, friability, weight variation, drug content, wetting time, <em>in vitro</em> disintegration time, <em>in vitro</em> dissolution.</p><p><strong>Conclusion: </strong>Finally concluded that the oro dispersible tablet of fluoxetine hydrochloride formulated by sublimation method by using crospovidone at 4.5% level used for depression treatment.</p> ER -