TY - JOUR AU - Mohana, Manoharan AU - Padma, Palghat Raghunathan PY - 2016/04/07 Y2 - 2024/03/29 TI - FREE RADICAL SCAVENGING ACTIVITY OF THE BACOSIDE FRACTION FROM BACOPA MONNIERI JF - International Journal of Current Pharmaceutical Research JA - Int J Curr Pharm Sci VL - 8 IS - 2 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijcpr/article/view/12101 SP - 61-64 AB - <p class="Default"><strong>Objective:</strong><em> Bacopa monnieri</em> is a herb which has been used in Indian traditional medicine for a long period. Bacosides, the major constituents of <em>Bacopa monnieri</em>, have antioxidant, anticancer and memory enhancing properties.</p><p class="Default"><strong>Methods:</strong> The bacoside fraction was isolated from the dried powder of the aerial parts of <em>Bacopa monnieri</em>. The free radical scavenging activity of the bacoside fraction was determined by different assays (DPPH, ABTS, SO<sup>●</sup>, NO<sup>●</sup>, OH<sup>●</sup> and H<sub>2</sub>O<sub>2</sub>) at concentrations ranging from 5 µg to 200 µg.</p><p class="Default"><strong>Results:</strong> The scavenging activity was increased in a dose-dependent manner from 5µg to 50 µg and a plateau in activity was observed from concentrations higher than 50 µg of the bacoside fraction.</p><p class="Default"><strong>Conclusion: </strong>Higher concentrations did not show further increase in scavenging activity. Various <em>in vivo</em> and <em>in vitro</em> studies are needed to assess the medicinal potential of the bacoside fraction</p> ER -