TY - JOUR AU - Mangaiyarkkarasi, P. AU - Arulantony, S. PY - 2016/07/01 Y2 - 2024/03/28 TI - DNA CLEAVAGE, CYTOTOXIC ACTIVITIES, AND ANTIMICROBIAL STUDIES OF SOME NOVEL SCHIFF BASE TRANSITION METAL COMPLEXES DERIVED FROM 4-AMINOANTIPYRINE AND DIHYDROPYRIMIDONE OF VANILLIN JF - International Journal of Current Pharmaceutical Research JA - Int J Curr Pharm Sci VL - 8 IS - 3 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijcpr/article/view/13879 SP - 43-47 AB - <p><strong>Objective: </strong>A novel series of transition metal complexes of Ni(II), Zn(II), Cd(II) and Hg(II) have been synthesized from the Schiff base derived from dihydropyrimidone derivative of vanillin (Biginelli Product) and 4-aminoantipyrine.</p><p><strong>Methods: </strong>The antimicrobial screening of the ligand and its complexes have been extensively studied on bacterias like <em>E. coli, Vibrio spp., Staphylococcus aureus, Pseudomonas aeroginosa, Bacillus spp., Vibrio para haemolytic's, Salmonella spp., Aeromonas spp., Klebsiella spp., Proteus spp.</em> and fungi such as <em>Candida albicans, Aspergillus flavus, Pencillium spp., Aspergillus niger, Trichophyton.</em></p><p><strong>Results: </strong>The metal complexes show greater activity than ligand. The antimicrobial activity of the complexes follows the order Hg&lt;Zn&lt;Cu. The DNA cleaving activity of Schiff base ligand and its metal complexes was examined using, <em>Hep 2</em> DNA as a target molecule by gel electrophoresis method. The Cu Complex-induced the DNA fragmentation with a specific activity. The <em>in vitro</em> cytotoxic effect of ligand and complex against <em>Normal VERO</em> and <em>Hep2 </em>was evaluated by MTT assay.</p><p><strong>Conclusion: </strong>The effect of [CuL<sub>2</sub>]Cl<sub>2</sub> was found to be stronger than the other compounds even at its lower concentrations.</p> ER -