TY - JOUR AU - PAWAR, P. Y. AU - M., WAGHMARE SWEETI PY - 2020/05/15 Y2 - 2024/03/28 TI - SYNTHESIS AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF QUINAZOLINONE DERIVATIVES JF - International Journal of Current Pharmaceutical Research JA - Int J Curr Pharm Sci VL - 12 IS - 3 SE - Original Article(s) DO - 10.22159/ijcpr.2020v12i3.38318 UR - https://journals.innovareacademics.in/index.php/ijcpr/article/view/38318 SP - 114-116 AB - <p><strong>Objective: </strong>The present study aims to synthesis and evaluation of antimicrobial activity of quinazolinone derivatives.</p><p><strong>Methods: </strong>Methyl anthranilate react with acetyl chloride in ethanol gives methyl-2 acetamido benzoate (1) which on reaction with hydrazine hydrate gives 3-amino-2 methyl 4-(3<em>H</em>)-quinazolinone.(2) The amino group of synthesized quinazolinone with substituted acid chloride which gives 3-Chloroacetyl amino-2-methyl-4-quinazolinone (3) which on condensation with various primary amines gives 2-(2-methyl-4-oxo-4<em>H</em>-quinazoline-3yl-amino)-N-substituted acetamide (4a-4j).</p><p><strong>Results: </strong>The reaction sequence involves microwave-induced preparation of methyl-2 acetamido benzoate (1) from reaction of Methyl anthranilate react with acetyl chloride in ethanol. Further reaction with hydrazine hydrate gives 3-amino-2 methyl 4-(3<em>H</em>)-quinazolinone. (2) The amino group of synthesized quinazolinone with substituted acid chloride which gives 3-Chloroacetyl amino-2-methyl-4-quinazolinone (3) which on condensation with various primary amines gives 2-(2-methyl-4-oxo-4<em>H</em>-quinazoline-3yl-amino)-N-substituted acetamide (4a-4j).</p><p>Which were characterized by IR and <sup>1</sup>HNMR spectral data.</p><p><strong>Conclusion: </strong>All the synthesized compounds were screened for antimicrobial activity by Broth dilution method. Most of the derivatives showed good antimicrobial activity against Gram-Positive and Gram-negative bacteria.</p> ER -