ESTIMATION EFFICACY OF ANTITHROMBOTIC ACTIVITY OF VARIOUS ANTIPLATELET DRUGS IN MURINE MODEL
Objective: To estimate antithrombotic effect of antiplatelet drugs, in collagen epinephrine treated swiss mice. Materials and Methods: Lung damage (pulmonary thromboembolism) in swiss mice treated with collagen (1.5 mg/kg) and epinephrine (0.5 mg/kg) by tail vein was studied by assessing parameters such as percentage protection. The effect of antiplatelet drugs (30ÂµM oral) on above parameters was investigated .This biochemical observations were supplemented by histological examination of lung sections. The data from the dose response studies were subjected to one-way ANOVA followed by post hoc Bonferroni's Multiple Comparison test. Results: Administration of antiplatelet drugs (30ÂµM oral) significantly increased percentage protection against collagen epinephrine induced pulmonary thromboembolism. Histological examination of lung sections revealed less thrombi generation, after administration of various antiplatelet drugs. Conclusions: The study suggests preventive action of antiplatelet drugs in collagen epinephrine induced pulmonary thromboembolism.
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