EVALUATION OF ANTIARTHRITIC ACTIVITY OF SCHISANDRA GRANDIFLORA AGAINST FORMALDEHYDE-INDUCED ARTHRITIS IN RATS

Authors

  • CHALLA PRADEEP KUMAR Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar, Telangana, India.
  • PENCHALA PRATHAP Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar, Telangana, India.
  • MUNAWWAR HUSAIN KAZMI Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar, Telangana, India.
  • RAVALI MARATI Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar, Telangana, India.

Keywords:

Schisandra grandiflora, Formaldehyde, Indomethacin

Abstract

Objective: Schisandra grandiflora is a plant, reported for its variety of ethnic medicinal uses. The current study was undertaken to evaluate the antiarthritic activity of S. grandiflora against formaldehyde-induced arthritis in rats.

Methods: The plant powder successively extracted with water and subjected for phytochemical screening to identify the different phytochemical constituents. LD50 study is conducted for the aqueous extract up to the dose level of 2000 mg/kg by following the method of OECD guidelines no. 425.

Results: Preliminary phytochemical studies revealed the presence of terpenoids, flavonoids, alkaloids, and glycosides in aqueous extract of S. grandiflora. No mortality was observed with the aqueous up to the maximum dose level of 2000 mg/kg. Further, aqueous extracts at 100 and 200 mg/kg, p.o but not with 100 mg/kg p.o dose significant (p<0.01) reduced paw edema in formaldehyde-induced arthritis in rats.

Conclusion: The present study revealed the antiarthritic activity extract of S. grandiflora. Moreover, the activity is showed the presence of phytochemical constituents such as terpenoids, alkaloids, glycosides, and flavonoids as these phytochemical constituents.

References

Available from: http://www.en.wikipedia.org/wiki/Arthritis.

Jawad M, Kaizal AF, Hameed IH. Medicinal plants used for the treatment of rheumatoid arthritis: A review. Int J Pharm Clin Res 2016;8:1685-94.

Wadekar JB, Sawant RL, Patel UB. Rheumatoid arthritis and herbal drugs: A review. J Phytopharmacol 2015;4:311-8.

Panossian A, Wikman G. Pharmacology of Schisandra chinensis Bail: An overview of Russian research and uses in medicine. J Ethnopharmacol 2008;118:183-212.

Choudhary M. Anti-arthritic activity of Barleria prionitis Linn leaves in acute and chronic models in Sprague Dawely rats. Bull Fac Pharm Cairo Univ 2014;52:199-209.

Evaluation of anti-arthritic activity of ethanolic extract of Sida cordifolia. Int J Sci Technol Res 2015;4:86-96.

Reddy JS, Rao GD, Lakshmi GR. A review on anti-arthritic activity of some medicinal plants. J Glob Tends Pharm Sci 2014;5:2061-73.

Rathor RS, Goyal HR, Studies on the anti-inflammatory and anti-arthritic activity of an Indian medicinal plant. Indian J Pharmacol 1973;5:334.

Shafeeq KA, Senthamarai R, Sundari SK. In vivo anti-arthritic activity of aqueous extract of Enicostemma axillare against formaldehyde induced arthritis. Res J Pharm Biol Chem Sci 2013;4:110-5.

OECD Guidelines for Acute oral Toxicity. Environmental Health and Safety Monograph Series on Testing and Adjustment No. 425.

Guha P, Das A, Paul S, Halder B. Analyses of human and rat clinical parameters in rheumatoid arthritis raise the possibility of use of crude Aloe vera gel in disease amelioration. Immunome Res 2014;10:2-7.

Bhujade A, Talmale S, Patil MB. In vivo studies on anti-arthritic activity of Cissus quadrangularis against adjuvant induced arthritis. J Clin Cell Immunol 2015;6:327.

Eastham RD, Szekely P, Davison K. C-reactive protein rheumatic heart disease. Ann Rheum Dis 1958;17:314-8.

Thomasq L. Clinical Laboratory Diagnostics. 1st ed. Berlin, New York: Walter de Gruyter; 1988.

Brun J. Proteasome inhibition as a novel therapy in treating rheumatoid arthritis. Med Hypotheses 2008;71:65-72.

Satoskar RS, Bhandarkar SD, Pure SS. Pharmacology and Pharmacotherapeutics. 18th ed. Mumbai: Popular Prakashan; 2003.

Tripathi KD. Essentials of Medical Pharmacology. 5th ed. New Delhi: Jaypee Brothers; 2003. p. 226.

Published

01-11-2019

How to Cite

CHALLA PRADEEP KUMAR, PENCHALA PRATHAP, MUNAWWAR HUSAIN KAZMI, & RAVALI MARATI. (2019). EVALUATION OF ANTIARTHRITIC ACTIVITY OF SCHISANDRA GRANDIFLORA AGAINST FORMALDEHYDE-INDUCED ARTHRITIS IN RATS. Innovare Journal Health Sciences, 7(6). Retrieved from https://innovareacademics.in/journals/index.php/ijhs/article/view/35874

Issue

Section

Original Article(s)