@article{K. NATARAJAN_Rashid_Shuhaib_Balu_2014, title={AZIMA TETRACANTHA LAM. AGAINST CAUSATIVE AGENTS IN DIABETIC FOOT INFECTIONS}, volume={2}, url={https://journals.innovareacademics.in/index.php/ijhs/article/view/2342}, abstractNote={<p><strong>Objective: </strong><em>Azima tetracantha</em> Lam.<strong> </strong> (Salvadoraceae), a widely growing herb has been used in the traditional medicine for treating many ailments. The objective of the present study was to evaluate the antimicrobial activity of aqueous extract of <em>A. tetracantha</em> leaves (AEAT) against the causative agents in diabetic foot infections and to understand the major phyto-constituents.</p><p><strong>Methods:</strong> Susceptibility analysis was carried out by disc diffusion method at two different concentrations of AEAT ‘<em>viz’</em> 500 &1000 µg/ml. UHPLC-ESI MS/MS was carried over with C<sub>18</sub> RP column using gradient mobile system and the spectrum obtained was interpreted.</p><p><strong>Results:</strong> All the strains tested were more susceptible to AEAT with maximum of 15mm inhibition observed for <em>Aspergillus niger</em> and <em>Klebseilla pneumoniae</em>. UHPLC-ESI MS/MS study confirmed the presence of Isorhamnetin-3-O-rutinoside, Myricetin and Friedelin in AEAT.</p><p><strong>Conclusion:</strong>  To conclude AEAT is found to be a good source of lead compounds in diabetic foot infections.</p><p> </p><p> <strong>KEYWORDS </strong><em>Azima tetracantha</em>, UHPLC ESI-MS/MS, antimicrobial</p>}, number={2}, journal={Innovare Journal Health Sciences}, author={K. NATARAJAN and Rashid, T. and Shuhaib, CK. and Balu, V.}, year={2014}, month={Oct.}, pages={9–12} }