ANTIOXIDANT, ANTI-INFLAMMATORY AND DIABETES RELATED ENZYME INHIBITION PROPERTIES OF LEAVES EXTRACT FROM SELECTED VARIETIES OF PHOENYX DACTYLIFERA L.


Laouini Salah Eddine

Abstract


Objective: to investigate the antioxidant, anti-inflammatory, and antidiabetic activities of ethanolic leaves extracts of three selected varieties of Phoenyx dactylifera L. namely: “Ghars”, “Deglet Nour” and “Hamraya”. Methods: The assessment of the antioxidant potential of crude leaves extracts, using superoxide anions inhibition, DPPH and total antioxidant activity essays, was carried out. Furthermore, the anti-inflammatory properties of the extracts were determined by measuring the inhibition of nitric oxide (NO) production. Moreover, the antidiabetic effect was evaluated by inhibition of α-amylase and α-glucosidase enzymes. The total phenolic content measured by Folin-ciocalteu method was as well conducted. Results: The raw leaves extracts of the selected varieties was found to contain a high content of total phenolic content (342.45 mg GAE/ gDW for GE) and therefore exhibited a higher antioxidant activity and inhibitory effect of radicals scavenging activity against DPPH and superoxide anion (IC50=7.44 μg/mL and 39.11 μg/mL respectively). The three varieties exhibited significant anti-inflammatory effects using in-vitro inhibition of NO (IC50=240.28 μg/mL for GE). The extracts also displayed high inhibition actions against α-amylase. Conclusion: the results suggest that the leaves of the three selected varieties of Phoenyx dactylifera can be considered as a good source of natural antioxidant and anti-inflammation drugs as well as potent antidiabetic medicine.


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About this article

Title

ANTIOXIDANT, ANTI-INFLAMMATORY AND DIABETES RELATED ENZYME INHIBITION PROPERTIES OF LEAVES EXTRACT FROM SELECTED VARIETIES OF PHOENYX DACTYLIFERA L.

Date

01-04-2013

Additional Links

Manuscript Submission

Journal

Innovare Journal of Life Sciences
Vol 1 Issue 1 2013 (Apr-Jun) Page: 14-18

Online ISSN

2321-550X

Statistics

1440 Views | 412 Downloads

Authors & Affiliations

Laouini Salah Eddine
Faculty of science and technology, El Oued university, Algeria
Algeria


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