PROTECTIVE EFFECT OF ABUTILON INDICUM L. (MALVACEAE) AGAINST ACETAMINOPHEN INDUCED NEPHROTOXICITY IN RATS
Acetaminophen overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms. The effects of ethanolic extract of Abutilon Indicum[200 mg per kg of body weight (mg/kg) and 400 mg/kg] on Acetaminophen induced nephrotoxicity were evaluated. Rats were divided into five groups containing 6 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), Acetaminophen alone (750 mg/kg), 750 mg/kg Acetaminophen+200 mg/kg extract (Acetaminophen+ 200-extract), and 750 mg/kg Acetaminophen+400 mg/kg extract (Acetaminophen+400-extract), respectively, for seven consecutive days. TheÂ EEAI was given orally concurrent with oral administration of Acetaminophen Treatment withÂ EEAI at doses of 200 and 400 mg/kg prevented the Acetaminophen-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of Serum creatinine, BUN, serum alkaline phosphatase, Serum uric acid, serum total proteins and total cholesterol. The nephroprotective effects ofÂ EEAI were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover,Â EEAI administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, EEAI has a protective role against Acetaminophen-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.
Key words: Antioxidants, Cisplatin, nephrotoxiciity, Abutilon indicum
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