PROTECTIVE EFFECT OF ABUTILON INDICUM L. (MALVACEAE) AGAINST ACETAMINOPHEN INDUCED NEPHROTOXICITY IN RATS

Authors

  • USHAKIRAN REDDY.T JNTU ANANTAPUR
  • MOHANA LAKSHMI. S
  • ASHOK KUMAR C. K
  • PRATHYUSHA. S
  • SATEESH KUMAR. D

Abstract

Acetaminophen overdose can cause nephrotoxicity with oxidative stress as one of the possible mechanisms. The effects of ethanolic extract of Abutilon Indicum[200 mg per kg of body weight (mg/kg) and 400 mg/kg] on Acetaminophen induced nephrotoxicity were evaluated. Rats were divided into five groups containing 6 rats each. The control group received distilled water while other groups were treated with extract alone (400 mg/kg), Acetaminophen alone (750 mg/kg), 750 mg/kg Acetaminophen+200 mg/kg extract (Acetaminophen+ 200-extract), and 750 mg/kg Acetaminophen+400 mg/kg extract (Acetaminophen+400-extract), respectively, for seven consecutive days. The EEAI was given orally concurrent with oral administration of Acetaminophen Treatment with EEAI at doses of 200 and 400 mg/kg prevented the Acetaminophen-induced nephrotoxicity and oxidative impairments of the kidney, as evidenced by a significantly reduced (P<0.05) level of Serum creatinine, BUN, serum alkaline phosphatase, Serum uric acid, serum total proteins and total cholesterol. The nephroprotective effects of EEAI were confirmed by a reduced intensity of renal cellular damage, as evidenced by histological findings. Moreover, EEAI administered at 400 mg/kg was found to show greater protective effects than that at 200 mg/kg. In conclusion, EEAI has a protective role against Acetaminophen-induced nephrotoxicity and the process is probably mediated through its antioxidant properties.

Key words: Antioxidants, Cisplatin, nephrotoxiciity, Abutilon indicum

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Published

01-07-2013

How to Cite

REDDY.T, U., LAKSHMI. S, M., KUMAR C. K, A., S, P., & D, S. K. (2013). PROTECTIVE EFFECT OF ABUTILON INDICUM L. (MALVACEAE) AGAINST ACETAMINOPHEN INDUCED NEPHROTOXICITY IN RATS. Innovare Journal of Life Sciences, 1(2), 40–43. Retrieved from https://innovareacademics.in/journals/index.php/ijls/article/view/281

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