APPROACHES FOR TASTE MASKING USING STEVIA LEAF IN PHARAMCEUTICALS


Deepak Sharma, Bhavesh Joshi, Rahul Kumar Garg, Ashok Dashora, deepak sahu, Piyush Agrawal, Piyush Mehta

Abstract


Oral administration of pharmaceuticals is one of the most popular method of drug dilevery.Taste is an important factor in the development of dosage form. Many active Pharmaceutical ingredients are bitter and require some form of taste masking to yield palatable drug products. Proven methods for bitterness reduction and inhibition have resulted in improved palatability of oral pharmaceuticals. Several approaches like adding flavors and sweeteners, use of lipoproteins for inhibiting bitterness, coating of drug with inert agents, microencapsulation, multiple emulsion, viscosity modifiers, liposome, prodrug formation, salt formation, formation of inclusion and molecular complexes, solid dispersion system and application of ion exchange resins have been tried by the formulators to mask the unpleasant taste of the bitter drugs but these methods are highly cost effective. Stevia rebaudiana Bertoni, source of a high-potency natural sweetener and produces diterpene glycosides that are low calorie sweeteners, about 300 times sweeter than saccharose with addition inclusion of without interfere.


| PDF |

References


Abou-Arab, A., Abou-Arab, A., & Abu-Salem, M. F. (2010). Physico-chemical assessment of natural sweeteners steviosides produced from Stevia rebaudiana Bertoni plant. African Journal of Food Science, 4, 269–281.

Adotey, D., Serfor-Armah, Y., Fianko, J., & Yeboah, P. (2009). Essential elements content in core vegetables grown and consumed in Ghana by instrumental neutron activation analysis. African Journal of Food Science, 3, 243–249.

Ahmad, N., Fazal, H., Abbasi, B., & Farooq, S. (2010). Efficient free radical scavenging

Activity of Ginkgo biloba, Stevia rebaudiana and Parthenium hysterophorous leaves through DPPH (2,2-diphenyl-1-picrylhydrazyl). International Journal of Phytomedicine, 2, 231–239.

Ahmed, M., & Dobberstein, R. (1982). Extraction, separation and recovery of diterpene glycosides from Stevia rebaudiana plants. US Patent 4, 361, 697.

Akashi, H., & Yokoyama, Y. (1975). Security of dried-leaf extracts of Stevia: Toxicological tests. Food Industry, 18, 34–43.

Amzad-Hossain, M., Siddique, A., Mizanur-Rahman, S., & Amzad-Hossain, M. (2010). Chemical composition of the essential oils of Stevia rebaudiana Bertoni leaves. Asian Journal of Traditional Medicines, 5, 56–61.

Anton, S., Martin, C., Han, H., Coulon, S., Cefalu, W., Geiselman, P., et al. (2010). Effects of Stevia, aspartame, and sucrose on food intake, satiety and postprandial glucose and insulin levels. Appetite, 55, 37–43.

Atteh, J., Onagbesan, O., Tona, K., Decuypere, E., Geuns, J., & Buyse, J. (2008). Evaluation of supplementary Stevia (Stevia rebaudiana Bertoni) leaves and stevioside in broiler diets: Effects on feed intake, nutrient metabolism, blood parameters and growth performance. Journal of Animal Physiology and Animal Nutrition, 92, 640–649.

Hiremath JG, Shatry CS, Srinath MS. Pharmaceutical approaches of taste masking in oral dosage forms. Indian Drugs, 2004. 41(5):p.253-257.

Antonio VG, Liliana ZB, Kong AH,Review:Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects,Food Chemistry ,2012.:p1121–1132.

Roberto LM, Antonio VG , Liliana ZB , Kong AH,Review:Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects, Food Chemistry .2012,132 :p.1121–1132




About this article

Title

APPROACHES FOR TASTE MASKING USING STEVIA LEAF IN PHARAMCEUTICALS

Date

01-04-2013

Additional Links

Manuscript Submission

Journal

Innovare Journal of Life Sciences
Vol 1 Issue 1 2013 (Apr-Jun) Page: 34-37

Online ISSN

2321-550X

Statistics

777 Views | 504 Downloads

Authors & Affiliations

Deepak Sharma
India

Bhavesh Joshi
India

Rahul Kumar Garg
India

Ashok Dashora
India

deepak sahu

Piyush Agrawal
India

Piyush Mehta
India


Refbacks