DESIGN, DEVELOPMENT AND EVALUATION OF LIPID BASED TOPICAL FORMULATIONS OF SILVER SULFADIAZINE FOR TREATMENT OF BURNS AND WOUNDS
Abstract
Abstract:
The aim of this research was to develop a novel lipid based film forming gel based on polymer and to investigate its potential as slow-release wound healing vehicle. The lipid based is composed of water soluble gel with model drug (Silver Sulfadiazine) and an egg oil, which acted as a remove scars. The morphology, rheology, mechanical properties, in-vitro drug release profiles were investigated. A smooth film layers was produced. The characterization results showed that film has superior mechanical and rheological properties than the ointment and cream. The lipid based gel treating low suppurating wounds and suitable for slow release application on wound surfaces. The lipid based gel also provided a significant higher healing rate in-vivo, with well-formed epidermis with faster granulation tissue formation when compared to the controls. In conclusions, a novel polymer-based lipid film gel was developed and results suggested that they can be exploited as slow-release wound dressings.
Key Words: Wound healings, slow release, silver sulfadiazine and film gel
References
Sharman, D., 2003. Moist wound healing: a review of evidence, application and outcome. Diabetic Foot 6, 112–120.
Ovington, L.G., 2007. Advances in wound dressings. Clin. Dermatol. 25, 33–38.
Atiyeh, B.S., Hayek, S.N., Gunn, S.W., 2005. New technologies for burn wound closure and healing—review of the literature. Burns 31, 944–956.
Singer, A.J., Dagum, A.B., 2008. Current management of acute cutaneous wounds. N. Engl. J. Med. 359, 1037–1046.
Abdelrahman, T., Newton, H., 2011. Wound dressings: principles and practice.Surgery (Oxford) 29, 491–495.
Lawrence, J.C., 1994. Dressings and wound infection. Am. J. Surg. 167, S21–S24. .
Boateng, J.S., Matthews, K.H., Stevens, H.N.E., Eccleston, G.M., 2008. Wound healing dressings and drug delivery systems: a review. J. Pharm. Sci. 97, 2892–2923.