DESIGN, DEVELOPMENT AND EVALUATION OF LIPID BASED TOPICAL FORMULATIONS OF SILVER SULFADIAZINE FOR TREATMENT OF BURNS AND WOUNDS


Piyush Mehta, Deepak Sharma, Ashok Dashora, Deepak Sahu, Rahul Kumar Garg, Piyush Agrawal, Deepak N. Kapoor

Abstract


Abstract:

The aim of this research was to develop a novel lipid based film forming gel based on polymer and to investigate its potential as slow-release wound healing vehicle. The lipid based is composed of water soluble gel with model drug (Silver Sulfadiazine) and an egg oil, which acted as a remove scars. The morphology, rheology, mechanical properties, in-vitro drug release profiles were investigated. A smooth film layers was produced. The characterization results showed that film has superior mechanical and rheological properties than the ointment and cream. The lipid based gel treating low suppurating wounds and suitable for slow release application on wound surfaces. The lipid based gel also provided a significant higher healing rate in-vivo, with well-formed epidermis with faster granulation tissue formation when compared to the controls. In conclusions, a novel polymer-based lipid film gel was developed and results suggested that they can be exploited as slow-release wound dressings.

Key Words: Wound healings, slow release, silver sulfadiazine and film gel


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References


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About this article

Title

DESIGN, DEVELOPMENT AND EVALUATION OF LIPID BASED TOPICAL FORMULATIONS OF SILVER SULFADIAZINE FOR TREATMENT OF BURNS AND WOUNDS

Date

01-04-2013

Additional Links

Manuscript Submission

Journal

Innovare Journal of Life Sciences
Vol 1 Issue 1 2013 (Apr-Jun) Page: 38-47

Online ISSN

2321-550X

Statistics

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Authors & Affiliations

Piyush Mehta
India

Deepak Sharma
India

Ashok Dashora
India

Deepak Sahu
India

Rahul Kumar Garg
India

Piyush Agrawal
India

Deepak N. Kapoor
India


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