TY - JOUR AU - S, RAJESWARI AU - R, Vidhya PY - 2017/07/01 Y2 - 2024/03/28 TI - EVALUATION OF IN VITRO THROMBOLYTIC AND ANTIPROTEINASE ACTIVITIES OF WEDELIA TRILOBATA (LINN.) JF - Innovare Journal of Life Sciences JA - Innovare J Life Sci VL - 5 IS - 3 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijls/article/view/18791 SP - 6-10 AB - <p><strong>ABSTRACT</strong></p><p><strong>Objective:</strong><em> </em>To determine the phytoconsistutents and <em>in vitro</em> thrombolytic and antiproteinase activities<em> </em>of<em> </em>aqueous extracts of leaf, stem and root of <em>Wedelia trilobata</em>.</p><p><strong>Methods:</strong> <em>In vitro</em> thrombolytic activity of aqueous extracts of different parts of <em>W. trilobata</em> against thrombolysis. <em>In vitro</em> antiproteinase activity of aqueous extracts of different parts of <em>W. trilobata.</em><strong> </strong></p><p><strong>Results:</strong> Phytochemical screening of aqueous extracts of leaf, stem and flower of <em>W. trilobata</em> showed various bioactive constituents such as carbohydrates, protein, phenols, tannins, saponins, alkaloids, terpenoids and quinines in all three parts of aqueous extracts. The maximum dissolution of blood clot (thrombolysis or fibrinolysis) was observed in leaf extracts, when compared to stem and extracts of flower <em>W. trilobata</em>. The highest degree of proteinase activity was showed in stem of <em>W. trilobata. </em></p><p><strong>Conclusions:</strong><em> </em>Since the aqueous extracts of different part of <em>W. trilobata </em>possess pharmacological active phytocompounds may be responsible for thrombolytic and antiproteinase activities<em>.</em> In further, to isolate the phytocompounds from this plant may be substantiate an effective drug in pharmacologic aspect as thrombolytic and anti inflammatory therapy.</p><p><strong>Keywords: </strong><em>Wedelia trilobata</em>, leaf, stem, flower, aqueous extracts.</p><p> </p><p> </p> ER -