INVESTIGATING THE RELATIONSHIP BETWEEN SERUM LEPTIN LEVELS AND C-REACTIVE PROTEIN IN POLY CYSTIC OVARY SYNDROME (PCOS) PATIENTS

Abstract

 

Objective: Despite the using of some biological and clinical criteria for definition of Polycystic ovarian syndrome, such as hyperandrogenism and menstrual dysfunction. However, the complex mechanism of this syndrome is still of interest to researchers, and began to investigate new parameters intervene in the pathogenesis of this disease, including leptin and C-reactive protein (CRP). However, the role of these parameters are still not clear and under controversy. This study, aimed to investigate the relationship between serum leptin levels with C-reactive protein in patients diagnosed with polycystic ovarian syndrome attending Aleppo gynecology university hospital.

Methods: The study includes 46 patients and 25 healthy control subjects with the same range of age- and body mass index. Related parameters were measured for both groups: serum glucose, leptin, insulin and C-reactive protein levels, and homeostasis model assessment of insulin resistance (HOMA-IR).

Results: Serum leptin levels were significantly correlated with C-reactive protein only in Polycystic ovarian syndrome group (p<0.05). The levels of C-reactive protein and leptin were significantly higher in the Polycystic ovarian syndrome group in comparison with the control group (p<0.05). There were a correlation between leptin with C-reactive protein only in patients with insulin resistance group (p > 0.05), and there was a correlation between C-reactive protein and HOMA-IR only in polycystic ovarian syndrome group (p>   0.001), but not in control group.

Conclusion: Increased leptin, C-reactive protein levels in polycystic ovarian syndrome patients is independently associated with insulin resistance and make these parameters more important to take them in consideration.

 Keywords: CRP, HOMA-IR, Leptin, PCOS.