• ADETUNJI OPEYEMI ADEBOLA Department of Anatomy, School of Basic Medical Sciences, Benjamin S. Carson (SNR.) College of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
  • OYEWO OLUWATOYIN Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
  • ADETUNJI IYABODE TOYIN Department of Pure and Applied Biology, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
  • NWOBI NNENA LINDA Department of Chemical Pathology, School of Pre-Clinical Sciences, Babcock University, Ogun State, Nigeria.


Aim and Objectives: Demonstrating the exact quantity of Moringa oleifera (MO) that will cure any hepatocyte diseases and the one that can harm the hepatocytes of the Adult Wistar rats.

Methods: Twenty (20) adult Wistar rats (both sex) were used for the study (caged based on same sex to avoid mating and pregnancy) and were randomly assigned into four groups (n=5); A-Control, B-250 mg/body weight (BW) of MO, C-500 mg/BW of MO, and D-750 mg/BW of MO orally.

Result: The crude aqueous extract of MO Lam, shows insignificant increased in BW at the 1st week of administration which latter dropped little by little doing the weeks of the administration in groups (B, C, and D) rats, by comparing (p<0.05) to the control group after MO administration, the organ (Kidneys) shows a significant difference between the kidneys (left and right kidneys) in relation to the control group rats. MO increases the weight of the animals morphologically by comparing the weight of the animals before and after administration. Histological sections shows a normal Glomerulli, Peri-Glomerular Space, Convoluted Tubules, and Interstitium, after administration of the Crude Aqueous Extract of MO lame in terms with the control group rats.

Conclusion: MO is a good herb that has no damage effect on the body and hepatocytes but of more beneficial.

Keywords: Crude Aqueous Extract, Moringa Oleifera Leaves, Kidney


1. Vanherweghem LJ. Misuse of herbal remedies: The case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy). J Altern Complement Med 1998;4:9-13.
2. Paul CW, Didia BC. The effect of methanolic extract of Moringa oleifera lam roots on the histology of kidney and liver of guinea pigs. Asian J Med Sci 2012;4:55-60.
3. Fahey JW. Moringa oleifera: A review of the medical evidence for its nutritional, therapeutic, and prophylactic properties. Part 1. Trees Life J 2005;1:5-15.
4. National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure. Circulation 2007;116:e99-109.
5. Moore KL, Dalley AF, Agur AM. Clinical Oriented Anatomy. 5th ed. Baltimore: Lippincott Williams and Wilkins; 2006.
6. Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 2001;109:69-75.
7. Harborne JB. Methods of plant analysis. In: Phytochemical Methods. Dordrecht: Springer; 1972. p. 1-32.
8. Uhegbu FO, Onwuchekwa CC, Iweala EE, Kanu I. Effect of processing methods on nutritive and antinutritive properties of seeds of Brachystegia eurycoma and Detarium microcarpum from Nigeria. Pak J Nutr 2005;8:316-20.
9. Nwinuka NM, Monanu MO, Nwiloh BI. Effects of aqueous extract of Mangifera indica L. (Mango) Stem bark on haematological parameters of normal albino rats. Pak J Nutr 2008;7:663-6.
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How to Cite
ADEBOLA, A. O., OLUWATOYIN, O., TOYIN, A. I., & NNENA LINDA, N. (2021). HISTOLOGICAL VARIANCES OF MORINGA OLIFERA ON THE KIDNEY OF ADULT WISTAR RATS. Innovare Journal of Medical Sciences, 9(3), 36-38. https://doi.org/10.22159/ijms.2021.v9i3.41144
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