• Hadijah Yamman Usman Federal University of Technology Minna


Malaria is still a major cause of severe illness which is responsible for millions of deaths, mostly in children under 5 years old.A major problem to malaria vaccine production is the identification of protective epitopes and respective protective antibody. A cross sectional study was carried out in a representative cohort of children in Minna aged 6 months to 17 years in order to determine the correlation between IgG antibody responses to Plasmodium falciparummerozoite antigens. Plasma samples from 93 children were exposed to Enzyme Linked Immunosorbent Assay (ELISA) for the measurement of immunoglobulin IgG antibody production against P. falciparum. There was a high seroprevalence of IgG antibody against P. falciparum antigens tested with 74.20%. The seroprevalence for the male category was quite higher as compared with that of the female category, though, analysis using Mann-Whitney U test revealed IgG antibody response to P. falciparum infection in the male was significantly different as compared to the female category (p<0.05). Furthermore, the prevalence of IgG antibody against P. falciparumantigen increased with age, with the lowest observed in 6 months to 5 years 66.66%.Kruskal-Wallis H test showed a non-significant difference in the production of IgG antibody againstP. falciparum antigen between differentcohorts, and no correlation exists between them (p>0.05). An evidence of more than 50% was found for the production of IgG antibody by sub-microscopic parasite. On the other hand, microscopically positive P. falciparum samples recorded more seroprevalence of 68.81% as against negative samples, though significant difference between the negative and positive P. falciparum infected samples and the production of IgG antibody was not observed (p>0.05).This study has demonstrateda boosting immune responses by sub-microscopic parasiteand also suggests a strong relationship between production of IgG antibody and malaria transmission, rather than protective immunity.

Keywords: Antibody, Antigen, ELISA, Immunoglobulin IgG, Malaria, Plasmodium falciparum


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