Prenatal and postnatal effect of lead acetate on the histology of frontal cortex and motor activity in Wistar rats


  • Saleh Nuhu Yusuf Maitama Sule University


Lead, neurodevelopment, prenatal, postnatal, motor activity


Background/aim: The frontal lobe is the part of the brain that controls important cognitive skills in humans, such as emotional expression, problem solving, memory, language, judgment, and sexual behaviors. Exposure of Wistar rats to lead (Pb) has been shown to have effects on the CNS, kidneys, bone marrow and other body systems. Therefore, this study was conducted in order to find the effect of lead on prenatally and postnatally exposed Wistar rats.

Methods: In this study, twelve (12) Wistar Rats were used and grouped into four groups of 2 females and 1 male. Group I rats served as the control andallowedfeed and water freely.  The rats in Group II were administered 500ppm of Pb through drinking water from gestation day 8 (GD8) to parturition (GD21). While, Group III rats were given 500ppm of Pb in drinking water from postnatal day 1 (PND1) to PND21. The rats in thefourth group (Group IV) were given 500ppm of Pb from GD8 to PND21. Palmer grasp reflex was conducted to assess the motor activity of the rat pups. The animals were then humanely sacrificed and thefrontal cortices were isolated for routine histological processing.

Results: The histological study has shown normal neurons in control group while degenerating cells exhibiting karyolysis, pyknosis, karyorrhexis, vacuolation were seen in the lead-treated groups. Group II and Group IV showed considerate deficit in their motor activity Group III mild effect.

Conclusion: From this study, lead exposure of Wistar rats at both prenatal and postnatal period of development has effect on the histology of the frontal cortex as well as on their motor activity.


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How to Cite

Nuhu, S. (2021). Prenatal and postnatal effect of lead acetate on the histology of frontal cortex and motor activity in Wistar rats. Innovare Journal of Medical Sciences, 9(6). Retrieved from



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