In-silico analysis of phytochemicals from Zingiber officinale for the inhibition of Tumour Protein 53BP1 (TP53-binding protein 1) associated with Hepatocellular Carcinoma(HCC)

Authors

  • SAMEER SHARMA Indian Academy Degree College - Autonomous

Keywords:

Hepatocellular Carcinoma, Phytocemicals, Ginger, Molecular docking, Lipinski rule, Ramachandran Plot, Visualisation.

Abstract

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. Studies have presented significance of the phytochemicals to inhibit the cancer. Certain class of phytochemicals are known to interact with the tumour protein TP53 at specific active sites to form complex causing inactivation. The paper investigates the interaction of the phytochemicals from Ginger (Zingiber officinale) with the Tumour protein TP53. Drug likeness of the chosen ligand was evaluated using SWISS ADME. AutoDockTools was used to carry the docking analysis and determine binding parameters with molecular modeling. Docking Visualization performed using PatchDock. The phytochemicals were investigated to be potential inhibitors of the tumour protein involved in Hepatocellular Carcinoma(HCC).

References

Brigitte, Debuire, Antoinette, Lemoine; Unité de Biologie Cellulaire du Noyau, CNRS URA 2582, Département de Biologie Cellulaire et Infection, Institut Pasteur, 25, Rue du Docteur Roux, 75724 Paris Cedex 15, France; Atlas of Genetics and Cytogenetics in Oncology and Haematology; [2001-10]

Rajagopal N. Aravalli,Clifford J. Steer,Erik N. K. Cressman; Molecular mechanisms of hepatocellular carcinoma; [24 November 2008]

PUBMED Website : https://pubmed.ncbi.nlm.nih.gov/

NCBI Website : https://www.ncbi.nlm.nih.gov/

Published

11-06-2022

How to Cite

SHARMA, S. (2022). In-silico analysis of phytochemicals from Zingiber officinale for the inhibition of Tumour Protein 53BP1 (TP53-binding protein 1) associated with Hepatocellular Carcinoma(HCC). Innovare Journal of Medical Sciences, 10(4). Retrieved from https://innovareacademics.in/journals/index.php/ijms/article/view/45113

Issue

Section

Original Article(s)