In-silico analysis of seaweed phytochemical Flavonoid for the inhibition of Staphylococcus enterotoxin A

Authors

  • SAMEER SHARMA Indian Academy Degree College - Autonomous

Keywords:

Staphylococcus enterotoxin A, Superantigen, S aureus, Flavonoids, Molecular docking, Lipinski rule, Ramachandran Plot.

Abstract

Staphylococcus enterotoxins are protein exotoxins synthesized by the Staphylococcus aureus. It is known to be responsible for causing gastrointestinal inflammation and toxic shock syndrome. Studies have presented the significance of the phytochemicals to inhibit the Staphylococcal enterotoxins. Flavonoids are known to interact with such protein exotoxins at specific active sites to form complex causing inactivation. The paper investigates the interaction of the phytochemical Flavones under the class of Flavonoids with the Staphylococcus enterotoxin A. Drug likeness of the chosen ligand was evaluated using SWISS ADME. AutoDockTools-1.5.6 was used to carry out the docking analysis and determine binding parameters with molecular modeling. Docking Visualization was performed using Discovery Studio. Phytochemicals under class Flavones, have set forth high binding affinity with the SEA protein complex which could assist in its inactivation.

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Published

11-06-2022

How to Cite

SHARMA, S. (2022). In-silico analysis of seaweed phytochemical Flavonoid for the inhibition of Staphylococcus enterotoxin A. Innovare Journal of Medical Sciences, 10(4). Retrieved from https://innovareacademics.in/journals/index.php/ijms/article/view/45116

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Section

Original Article(s)