• SWATHI S Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, PES University, Bengaluru, Karnataka, India.
  • LAKSHMAN K Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, PES University, Bengaluru, Karnataka, India.



Lannea coromandelica, Phytochemistry, Ethnobotanical uses, Pharmacological properties, Flavonoids


Lannea coromandelica is extensively employed as a medicinal herb across the globe. This research work focuses primarily on the phytochemistry, pharmaceutics, and bio-exertion of L. coromandelica. In ethnomedicine, several members of this species function as astringents, aiding in anti-oxidant, anti-inflammatory, and anti-diabetic and are helpful in other physiological functions. In addition, Lannea species’ therapeutic benefits were acknowledged in numerous scientific investigations. The conclusions derived from the current study corroborate that the therapeutic activities of L. coromandelica can be linked to the presence of a broad spectrum of secondary metabolites and bioactive phytocompounds such as phenols, flavonoids, tannins, and proteins, according to the current study. This review highlights phyto-assembly and phyto-activities such as a diuretic, cardiovascular, and bioactivities such as antiepileptic, antimicrobial, and anti-convulsant, and pharmaceutical activities such as anti-cancer, anti-diabetic, and anti-asthmatic properties.


Achika J, Ayo R, Oyewale A, James D. Chemical investigation and antioxidant activity of fractions of Lannea humilis (Oliv.) Engl. J Turk Chem Soc Sec A Chem 2017;4:563-72.

Alam B, Hossain S, Habib R, Rea J, Islam A. Antioxidant and analgesic activities of Lannea coromandelica Linn. Bark extract. Int J Pharmacol 2012;8:224-33.

Anderson DM, Hendrie A. The structure of Lannea coromandelica gum. Carbohydr Res 1973;26:105-15.

Antimicrobial Activity of Anogeissus leiocarpus and Lannea microcarpa on Some Microbes Isolated from Vegetables in Sokoto. Dubai, UAE: International Conference on Chemical, Environmental and Biological Sciences; 2015.

Kumar RB. Flora of sacred groves at Sriharikota Island, Andhra Pradesh, India. Ethnobot Leafl 2010;14:420-6.

Bingchun G, Rongtao L, Xinquan Y, Daolin D. Ethnobotanical study on medicinal plants used by Li nationality in Wuzhishan area of Hainan province. Afr J Pharm Pharmacol 2007;7:???.

Chandrajith VG, Marapana R. Physicochemical characteristics of bark exudates of Lannea coromandelica and its application as a natural fruit coating. J Pharmacogn Phytochem 2018;7:1798-1802.

Clarke AE, Anderson RL, Stone BA. Form and function of arabinogalactans and arabinogalactan-proteins. Phytochemistry 1979;18:521-40.

Das G, Ojha D, Bhattacharya B, Samanta M, Ghosh S, Datta S, et al. Evaluation of antimicrobial potentialities of leaves extracts of the plant Cassia tora Linn. (Leguminosae/Caesalpinioideae). J Phytol 2010;2:64-72.

Dinesh V, Sharma P. Traditional uses of plants in indigenous folklore of Nizamabad district, Andhra Pradesh, India. Ethnobot Leafl 2010;14:29-45.

Franco FM, Narasimhan D. Plant names and uses as indicators of knowledge patterns. Indian J Tradit Knowl 2009;8:645-8.

Galanki V, Venkatesham A, Chitturi D. Antidiabetic activity of Lannea coromandelica Houtt leaves in alloxan-induced diabetic rats. Int J Pharm Biol Sci 2014;4:108-14.

Muhaisen HM. Chemical constituents from the bark of Lannea acida rich (Anacardiaceae). Pharm Chem 2013;5:88-96.

Hossain J, Biswas S, Shahriar M, Chowdhury MM, Islam S. Chowdhury RA. Phytochemical screening, antimicrobial activity, antioxidant capacity, and in vivo anticancer activity of Lannea coromandelica bark extracts. IOSR J Pharm Biol Sci 2018;13:19-25.

Imam MZ, Moniruzzaman M. Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. J Ethnopharmacol 2014;154:109-15.

Islam MT, Tahara S. Dihydroflavonols from Lannea coromandelica. Phytochemistry 2000;54:901-7.

Islam MT, Ito T, Sakasai M, Tahara S. Zoosporicidal activity of polyflavonoid Tannin identified in Lannea coromandelica stem bark against phytopathogenic oomycete Aphanomyces cochlioides. J Agric Food Chem 2002;50:6697-703.

Islam R, Khan AS, Benozir S, Islam S, Alam J. Anti-diabetic properties of Lannea coromandelica L. bark extract on alloxan induced Type-2 diabetic rats. Eur J Pharm Med Res 2018;5:31-8.

John HB. Allergic Asian Anacardiaceae. Clin Dermatol 1986;4:191-203.

Manzur-Ul-Kadir Mia M, Kadir MF, Hossan MS, Rahmatullah M. Medicinal plants of the Garo tribe inhabiting the Madhupur forest region of Bangladesh. Am Eur J Sustain Agric 2009;3:165-71.

Kamalkishor HN, Kulkarni KM. Fish stupefying plants used by the Gond tribal of Mendha village of Central India. Indian J Tradit Knowl 2009;8:531-4.

Kantamreddi V, Lakshmi YN, Kasapu VV. Preliminary phytochemical analysis of some important Indian plant species. Int J Pharm Biol Sci 2010;1:358.

Kaur R, Jaiswal ML, Jain V. Protective effect of Lannea coromandelica Houtt. Merrill. Against three common pathogens. J Ayurveda Integr Med 2013;4:224-8.

Kumar T, Jain V. Appraisal of total phenol, flavonoid contents, and antioxidant potential of folkloric Lannea coromandelica using in vitro and in vivo assays. Scientifica 2015;2015:203679.

Lestari DW, Satria Y. The Utilization of Kudo Bark (Lannea coromandelica) as the Source of Natural Dye in Dyeing of Silk Batik. Vol. 1. Indonesia: Proceeding Indonesian Textile Conference; 2019. p. 1-6.

Manik MK, Wahid MA, Islam SM, Pal A, Ahmed KT. A comparative study of the antioxidant, antimicrobial and thrombolytic activity of the bark and leaves of Lannea coromandelica (anacardiaceae). Int J Pharma Sci Res 2013;19:2609-14.

Mannan A, Das H, Rahman M, Jesmin J, Siddika A, Rahman M, et al. Antihyperglycemic activity evaluation of Leucas aspera (Willd.) link leaf and stem and Lannea coromandelica (Houtt.) Merr. bark extract in mice. Adv Nat Appl Sci 2010;4:385-8.

Stanislaus N, Sule MI, Pateh UU, Hassan HS, Ahmed MM, Abdullahi ST, et al. Phytochemical and antimicrobial activity of the leaves of Lannea kerstingii Engl and k. Krause (Anacardiaceae). J Health Allied Sci NU 2014;4:4-9.

Olatokunboh AO, Mofomosara SH, Ekene OA. Evaluation of the antidiarrhoeal effect of Lannea welwitschii Hiern (Anacardiaceae) bark extract. Afr J Pharm Pharmacol 2010;4:165-9.

Picerno P, Mencherini T, Loggia RD, Meloni M, Sanogo R, Aquino RP. An extract of Lannea microcarpa: Composition, activity, and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. J Pharm Pharmacol 2006;58:981-8.

Prabhakaran M, Sundarapandian SM, Elumalai S. Phytochemical studies and antibacterial activity of the leaf, bark, and root powders of Odina wodier Roxb. Biosci Biotech Res Asia 2010;7:857-77.

Premjanu N, Jaynthy C, Diviya S. Antifungal activity of endophytic fungi isolated from Lannea coromandelica-an in silico approach. Int J Pharm Pharm Sci 2016;8:207-10.

Rahman MS, Begum B, Chowdhury R, Rahman KM, Rashid MA. Preliminary cytotoxicity screening of some medicinal plants of Bangladesh. Dhaka Univ J Pharm Sci 2008;7:47-52.

Rahman M, Khatun A, Uddin SJ, Shilpi JA. Comparative effect of Lannea coromandelica (Houtt.) Merr. leaves and stem barks on acetic acid-induced pain model in mice and chromogenic reagents: Exploring the analgesic potential and phytochemical groups. Pharmacol Online 2016;1:146-52.

Ramachandran R, Joshi BC. Examination of the gum from Lannea coromandelica. Phytochemistry 1968;7:2057-9.

Rao VS, Einstein JW, Das K. Hepatoprotective and antioxidant activity of Lannea coromandelica Linn on thioacetamide induced hepatotoxicity in rats. Int Lett Nat Sci 2014;8:30-43.

Reddy AK, Joy JM, Kumar CK. Lannea coromandelica: The researcher’s tree. J Pharm Res 2011;4:577-9.

Sathish R, Ahmed MH, Natarajan K, Lalitha KG. Evaluation of wound healing and antimicrobial activity of Lannea coromandelica (Houtt) Merr. J Pharm Res 2010;3:1225-8.

Selvaraj D, Kotapadu A, Sampurna B, Balaji P, Abraham AA, Kesavan SK, et al. Detection of active constituents from the leaf extract of Lannea coromandelica by GC-MS testing and assessment of its pharmacological activity. Int J Pharm Sci Res 2015;1:1217-21.

Seth MK. Trees and their economic importance. Bot Rev 2003;69:321-76.

Shahriyar SA, Sultana N, Haque M, Islam SM. Antihyperglycemic and antinociceptive activity of Lannea coromandelica (houtt.) Merr. Bark in vivo. World J Pharm Pharm Sci 2016;5:171-84.

Shrimal RL, Vyas LN. Community structure of the Mota Magra forest block (Udaipur). Vegetatio 1977;34:127-32.

Singh S, Singh GB. Hypotensive activity of Lannea coromandelica bark extract. Phytother Res 1996;10:429-30.

Subramanian SS, Nair AG. Polyphenols of Lannea coromandelica. Phytochemistry 1971;10:1939-40.

Upadhyay B, Parveen, Dhaker AK, Kumar A. Ethnomedicinal and ethnopharmaco-statistical studies of Eastern Rajasthan, India. J Ethnopharmacol 2010;129:64-86.

Vadivel K, Thangabalan B, Chetanajessygrace B, Kumar DP, Manoharbabu S, Narayana KV. Preliminary phytochemical evaluation of leaf extracts of Lannea corommandelica L. Int J Pharmacol Res 2012;2:64-68.

Valli G, Jeyalakshmi M. Preliminary phytochemical and antioxidant study of Odina woodier leaf extract. Asian J Pharm Res 2012;2:153-5.

Venkatesham A, Vasantha G, Dayakar CH. Hypolipidemic activity of Lannea coromandelica Houtt. leaves in triton X-100 induced hyperlipidemic rats. Indian J Pharm Pharmacol 2019;5:207-10.

Walunj S, Gupta R, Joshi S, Sabharwal S, Joshi K. Lannea coromandelica attenuates glucagon and oxyntomodulin mediated cAMP formation in HEK cells stably-expressing human glucagon receptors. J Herb Med 2015;5:153-7.

Wollenweber E, Dietz VH. Occurrence and distribution of free flavonoid aglycones in plants. Phytochemistry 1981;20:869-932.

Yun XJ, Shu HM, Chen GY, Ji MH, Ding JY. Chemical constituents from barks of Lannea coromandelica. Chin Herb Med 2014;6:65-9.

Wachtel-Galor S, Benzie IF. Herbal medicine An Introduction to Its History, Usage, Regulation, Current Trends, and Research Needs. Florida, United States: CRC Press/Taylor and Francis; 2011.

Ghasemian M, Owlia MB. A different look at pulsed glucocorticoid protocols; is high dose oral prednisolone necessary just after initiation of pulse therapy? J Case Rep Pract 2015;l3:1-3.

Rai PK, Lalramnghinglova H. Ethnomedicinal plant resources of Mizoram, India: Implication of traditional knowledge in health care system, Ethnobot Leafl 2010;14:274-305.

Beaman JH. Allergenic Asian Anacardiaceae. Clin Dermatol 1986;4:191-203.

Garcia-Ruiz JC, Amutio E, Ponta J. Invasive fungal infection in immunocompromised patients. Rev Iberoam Micol 2004;21:55-62.

Dismukes WE. Introduction to antifungal drugs. Clin Infect Dis 2000;30:653-7.

Tan RX, Zou WX. Endophytes: A rich source of functional metabolites. Nat Prod Rep 2001;18:448-59.

Strobel GA. Rainforest endophytes and bioactive products. Crit Rev Biotechnol 2002;22:315-8.

Ding G, Liu S, Guo L, Zhou Y, Che Y. Antifungal metabolites from the plant endophytic fungus Pestalotiopsis foedan. J Nat Prod 2008;71:615-8.

Strobel G, Daisy B. Bioprocessing for microbial endophytes and their natural products. Microbiol Mol Biol Rev 2003;67:491-502.

Mousa WK, Raizada MN. The diversity of anti-microbial secondary metabolites produced by fungal endophytes: An interdisciplinary perspective. Front Microbiol 2013;4:65.

Donadio S, Monciardini P, Alduina R, Mazza P, Chiocchini C, Cavaletti L, et al. Microbial technologies for the discovery of novel bioactive metabolites. J Biotechnol 2002;99:187-98.

Queiroz EF, Kuhl C, Terreaux C, Mavi S, Hostettmann K. New dihydroalkylhexenones from Lannea edulis. J Nat Prod 2003;66:578-80.

Merlin FF, Narasimhan D. Plant names and uses as indicators of knowledge patterns. Indian J Tradit Knowl 2009;8:645-8.

Rajagopal K. Endophytic fungi of a palm, Borassus flabellifer L. A first report from India. Asian J Microbiol Biotechnol Environ Sci 2004;6:541-4.

Venkatachalam CM, Jiang X, Oldfield T, Waldman M. Ligandfit: A novel method for the shape-directed rapid docking of ligands to protein active sites. J Mol Graph Model 2003;21:289-91.

Wicklow DT, Roth S, Deyrup ST, Gloer JB. A protective endophyte of maize: Acremonium zeae antibiotics inhibitory to Aspergillus flavus and Fusarium verticillioides. Mycol Res 2005;109:610-8.

Park JH, Choi GJ, Lee SW, Jang KS, Choi YH, Cho KY, et al. Screening for antifungal endophytic fungi against six plant pathogenic fungi. Mycobiology 2003;31:179-82.

Liu L, Liu S, Niu S, Guo L, Chen X, Che Y. Isoprenylated chromone derivatives from the plant endophytic fungus Pestalotiopsis fici. J Nat Prod 2009;72:1482-6.

Shekhawat KK, Rao DV, Batra A. In vitro antimicrobial activities of endophytic fungi isolates from medicinal tree-Melia azedarach L. J Microbiol Res 2013;3:19-24.

Liu JY, Song YC, Zhang Z, Wang L, Guo ZJ, Zou WX, et al. Aspergillus fumigatus CY018, an endophytic fungus in cynodon dactylon as a versatile producer of new and bioactive metabolites. J Biotechnol 2004;114:279-87.

Zhang CL, Zheng BQ, Lao JP, Mao LJ, Chen SY, Kubicek CP, et al. Clavatol and patulin formation as the antagonistic principle of Aspergillus clavatonanicus, an endophytic fungus of Taxus mairei. Appl Microbiol Biotechnol 2008;78:833-40.

Zhang YX, Li M, Wang CY, Wang BG. A new naphtha quinoneimine derivative from the marine algal-derived endophytic fungus Aspergillus niger EN-13. Chin Chem Lett 2007;18:951-3.

Loesgen S, Magull J, Schulz B, Draeger S, Zeeck A. Isofusidienols: Novel chromone-3-oxepines produced by the endophytic fungus Chalara sp. Eur J Org Chem 2008;4:698-703.

Kim JH, Campbell BC, Chan KL, Mahoney N, Haff RP. Synergism of antifungal activity between mitochondrial respiration inhibitors and kojic acid. Molecules 2013;18:1564-81.

Hoekstra WJ, Garvey EP, Moore WR, Rafferty SW, Yates CM, Schotzinger RJ. Design and optimization of highly-selective fungal CYP51 inhibitors. Bioorg Med Chem Lett 2014;24:3455-8.

Strushkevich N, Usanov SA, Park HW. 3 Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol 2010;397:1067-78.

Toda M, Okubo S, Ohnishi R, Shimamura T. Antibacterial and bactericidal activity of Japanese green tea. Nihon Saikingaku Zasshi 1989;44:669-72.

Fernandez MA, Garcia MD, Saenz MT. Antibacterial activity of the phenolic acids fraction of Scrophularia frutescens and Scrophularia sambusifolia. J Ethnopharmacol 1996;53:11-4.

Hoult JR, Paya M. Pharmacological and biochemical actions of simple coumarins: Natural products with therapeutic potential. Gen Pharmcol 1996;27:713-22.

Krishnaiah PV, Ratnam KV, Raju RR. Preliminary phytochemical evaluation of certain anticancer crude drugs used by adivasis of Rayalaseema Region, Andhra Pradesh, India. Ethnobot Leafl 2008;12:693-7.



How to Cite




Review Article(s)