NEUROPROTECTIVE ACTIVITIES AND REPAIR MECHANISMS OF GINKGO BILOBA EXTRACT EGB 761 ON CNS INJURIES AND NEURODEGENERATIVE DISORDERS
DOI:
https://doi.org/10.22159/ijms.2023.v11i2.47441Keywords:
Alzheimer’s, Parkinson’s, brain injury, neuroplasticity, free radical scavengers, subarachnoid hemorrhage, synaptogenesis, hypoxia.Abstract
With an increasing number of neurodegenerative diseases and brain injuries, the focus of the research using synthetic and herbal medicines with an objective to treat the existing problems in neuroscience is ever-increasing. The availability of natural resources, knowledge about ancient herbs, and the mechanisms underlying neurodegenerative disorders and brain injuries is essential to developing herbal supplements with the potential to treat brain diseases and injuries. Despite the variety of synthetically manufactured drugs for brain health, the need for herbal and natural supplements is ever-rising due to the adverse long-term side effects of synthetic drugs. Ginkgo biloba — an Asian plant that is known to possess various neuroprotective properties — has been used as a medicine, even before 1505 AD. G. biloba extract EGB761 has been known to treat and manage impaired nervous system disorders. The current review discusses the neuroprotective properties of G. biloba and its repair mechanisms against subarachnoid hemorrhage, central nervous system (CNS) injuries like traumatic brain injury, ischemic brain injury, early brain injury, spinal cord injury, hypoxia, neuronal apoptosis, neurodegenerative diseases like Alzheimer’s, Parkinson’s, neuroplasticity, neurogenesis, synaptogenesis and its free radical scavenging activity, and neuroleptic properties for a nutritional approach to manage neurodegenerative disorders and CNS injuries.
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