TY - JOUR AU - HADIJAH, YAMMAN-USMAN AU - CJ INNOCENT, OMALU AU - ABDULKADIR, ABUBAKAR AU - SO, ABOLARINWA AU - SAMUEL, EKE S AU - A CHIDIEBERE, OTUU PY - 2021/05/01 Y2 - 2024/03/29 TI - SEROPREVALENCE OF IMMUNOGLOBULIN IgG ANTIBODY RESPONSE TO PLASMODIUM FALCIPARUM MEROZOITE ANTIGENS AMONG CHILDREN IN MINNA, NORTH CENTRAL, NIGERIA JF - Innovare Journal of Medical Sciences JA - Innovare J Med Sci VL - 9 IS - 3 SE - Original Article(s) DO - 10.22159/ijms.2021.v9i3.41268 UR - https://journals.innovareacademics.in/index.php/ijms/article/view/41268 SP - 31-35 AB - <p><strong>Objective: </strong>A cross-sectional study was carried out in a representative cohort of children in Minna aged 6 months–17 years to determine the correlation between immunoglobulin G (IgG) antibody responses to <em>Plasmodium falciparum </em>merozoite antigens.</p><p><strong>Methods: </strong>Plasma samples from 93 children were exposed to Enzyme-Linked Immunosorbent Assay for the measurement of IgG antibody production against <em>P. falciparum. </em></p><p><strong>Results: </strong>There was a high seroprevalence of IgG antibody against <em>P. falciparum </em>antigens tested with 74.20%. The seroprevalence for the male category was quite higher as compared with that of the female category, though, analysis using Mann–Whitney <em>U-</em>test revealed IgG antibody response to <em>P. falciparum </em>infection in the male was significantly different as compared to the female category (p&lt;0.05). Furthermore, the prevalence of IgG antibody against <em>P. falciparum </em>antigen increased with age, with the lowest observed in 6 months–5 years 66.66%. Kruskal–Wallis <em>H </em>test showed a non-significant difference in the production of IgG antibody against <em>P. falciparum </em>antigen between different cohorts, and no correlation exists between them (p&gt;0.05). An evidence of more than 50% was found for the production of IgG antibody by sub-microscopic parasite. On the other hand, microscopically positive <em>P. falciparum </em>samples recorded more seroprevalence of 68.81% as against negative samples, though significant difference between the negative and positive <em>P. falciparum </em>infected samples and the production of IgG antibody was not observed (p&gt;0.05).</p><p><strong>Conclusion: </strong>This study has demonstrated a boosting immune responses by sub-microscopic parasite and also suggests a strong relationship between production of IgG antibody and malaria transmission, rather than protective immunity.</p> ER -