1Faculty of Science (Girls), Chemistry Department, Al-Azhar University, Nasr City, Cairo, Egypt, 2Nanochemistry and Nanoengineering, School of Chemical Engineering, Department of Chemistry and Materials Science, Aalto University, Kemistintie 1, 00076 Aalto, Finland, 3Department of Therapeutical Chemistry, Pharmaceutical Division, National Research Centre, Dokki 12311, Giza, Egypt
Objective: The present research aims to synthesize some new polycyclic compounds including chromene moiety and study their antimicrobial activity.
Methods: Several new polycyclic systems including chromene scaffold incorporated with pyridine, pyrimidine, imidazopyrimidine, and imidazodiazocine were achieved via condensation reaction of chromene derivative under the proper condition with various reagents namely; cyanothioacetamide, phenyl isothiocyanate, malononitrile, carbon disulfide, benzaldehyde, triethyl orthoformate, and 1,4-dichlorobutane. Moreover, a chlorodiazenyl chromene derivative was reacted with some substances possessing active–CH2-bridge such as ethyl cyanoacetate and malononitrile to end up with hydrazono compounds. Such compounds were eventually cyclized with hydrazine hydrate to form pyrazole and oxopyrazole derivatives. Moreover, compound 1 was treated with benzoyl acetone, and then followed by cyclization with malononitrile to provide the corresponding 2-amino14-(4-methoxyphenyl)-4-methy-5-phenyl-14H-benzo[5,6] chromeno [2,3H][1,6]naphthyridine-3-carbonitrile (20).
Results: The results of the antimicrobial screening in vitro revealed that the inhibition zone (mm) of the synthesized compounds 1-3, 5 and 8 implied their optimum antibacterial activity, while the compounds 4, 6 and 9-13, 15 showed a moderate to weak antibacterial activity against multiple species of B. subtilis, S. aureus, E. coli and P. aeruginosa. In contrast, the compounds 1, 6, 11, 15 showed high antifungal activities against different species of A. flavinand C. albicans, while the other compounds exhibit a moderate to poor antifungal activity.
Conclusion: It is remarkable that a series of chromene derivatives synthesized by a simple and available method leads to a molecule of promising antimicrobial activity. Further research is recommended to approve the importance of polycyclic systems for various applications.
Keywords: Chromene-3-carbonitrile, Chromenes, Polycyclic compounds, Pyrimidines, Fused ring, Antimicrobial activity
With regard to the publication in: International Journal of Pharmacy and Pharmaceutical Sciences entitled "Synthesis and Utility of New Polycyclic Compounds as potential Antimicrobial Based on Chromene Moiety" which is fully published in your respectable journal 2019 vol 11, issue 9. I have been significantly the corresponding author and contributing with team. It came to my attention that this manuscript now is published, Affiliation regarding to Finland should be removed (Nanochemistry nanoengineering School of chemical Engineering, Department of chemistry and Material science Aalto university, Finland) regarding to the corresponding author EMAN S ZARIE
Due to the reasons
Application for habilitation in Egypt needs only one affiliation.
Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Research Division National Research Centre, Dokki 12311, Giza, Egypt.
To complete the process of promotion in Egypt, the other Affiliation regarding to Finland should be removed.
I have originally done laboratory analysis of this manuscript using tools in Finland throughout the period of 2016. to2018 so,
Instead of removing this affiliation of Finland just adding acknowledgement in the part of Acknowledgement (The authors are gratefully to acknowledge the school of chemical Engineering at Aalto University, Finland and German Research Foundation (DFG), Germany for providing financial support for data analysis and characterization).
I necessarily request removing nanochemistry nanoengineering, Aalto University, Finland).
I keep my right to further this issue.
The affiliation would be
Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Research Division National Research Centre, Dokki 12311, Giza, Egypt