THE ANTI-CATARACT EFFECT OF COENZYME Q10 IN RABBITS


Baha'a A. Abdul Hussein, Ahmed Salim Mahmood

Abstract


Objective: cataract is the opacity of the lens which progressively impairs the light transmission to the retina and finally prevents the vision, these opacity result from the oxidative process in the eye. The study aimed to prevent opacity of the lens by using Coenzyme Q10 as eye drops.

Methods: Sodium selenite 0.01w/v injected intravitreal to the rabbit's eye to induce the disease, a group of rabbits were receive Coenzyme Q10 eye drop, and another group received distilled water, pre and post induction, cataract maturity was measured to evaluate the opacity deterioration.

Results: the group of rabbits that received distilled water after induction of cataract, the opacity occurred within 48-72 h and the mean score of opacity reached to (4±0.00), while Coenzyme Q10 treated group the degree of opacity was (1.5±0.02), and there was a highly significant difference (p<0.01).

Conclusion: Coenzyme q10 has an antioxidant activity when use as eye drops and this effect enable Coenzyme Q10 to prevent the opacity which is the major cause of cataract due to oxidative stress.


Keywords


Cataractogenesis, Oxidative stress, Coenzyme Q10

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References


Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J 1995;9:1173-82.

Huang L, Estrada R, Yappert MC, Borchman D. Oxidation-induced changes in human lens epithelial cells.1. Phospholipids. Free Radical Biol Med 2006;41:1425–32.

Horwitz J. Lens alpha-crystallin: function and structure. Eye (Lond) 1999;13:403-8.

Wu H, Yu Y, David L, Ho Y, F Lou M. Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in mice. J Biol Chem 2014;289:36125-39.

Marianne Shahsuvaryan. The management of cataract: where we are? EC Ophthalmol 2016;33:304-8.

Kupfer C Bowman lectures. The conquest of cataract: a global challenge. Trans Ophthalmol Soc UK 1985;104:1–10.

Boldyrev AA. The antioxidative properties of carnosine, a natural histidine-containing dipeptide. Biochem Int 1987;15:1105-13.

Groneberg DA, Kindermann B, Althammer M, Klapper M, Vormann J, Littarru GP, et al. Coenzyme Q10 affects the expression of genes involved in cell signaling, metabolism and transport in human CaCo-2 cells. Int J Biochem Cell Biol 2005;37:1208-18.

A W Linnane H. Eastwood: cellular redox poise modulation; the role of coenzyme Q10, gene and metabolic regulation. Mitochondrion 2004;4:779-89.

Rita Mencucci, Eleonora Favuzza, Carlotta Boccalini, Andrea Lapucci, Roberta Felici, Francesco Resta, et al. CoQ10-Containing eye drops prevent UVB-induced corneal cell damage and increase cornea wound healing by preserving mitochondrial function. Invest Ophthalmol Visual Sci 2014;55:7266-71.

Allen LV, Popovich NG, Ansel HC. Ansel’s pharmaceutical dossage forms and drug delivery systems. 8th ed. Lippincott Williams and Wilkins: Philadelphia; 2005.

Cotlier E. Physiology of the lens. In: Moses RA, Hart WM. Alder’s physiology of the clinical eye application. 9th ed. Mosby Company: St. Louis; 1995.

Samuel J, Ziegler JR, Datlies MB. Pathogenesis of cataracts. In: Thomas M, Aaberg SR, Richard L, Mark B, Dharam V. Duane's Foundations of Clinical Ophthalmology: Lippincott Williams and Wilkins; 2003.

Kanski J. Kanski clinical ophthalmology a systemic approach. 6th ed. Lippincott's: Philadelphia and Sant Louis; 2007.

American academy of ophthalmology; 2010. Available from: www.aao.com. [Last accessed on 20 Jan 2016]

Chylack LT, Wolfe JK, Singer DM, Leske MC, Bullimore MA, Bailey IL, et al. The lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol 1993;111:831-6.

Datiles MB, Magno BV. Cataract: clinical types. In: Thomas M, Aaberg SR, Richard L, Mark B, Dharam V. Duane's Foundations of Clinical Ophthalmology. Lippincott Williams and Wilkins: Philadelphia; 2003.

Macdonald M. The examination of the eye. In: Munro J, Edwards C. Macleod’s Clinical Examination. 10th. ed. Churchill Livingstone: Edinburgh; 2000.

Paton D, Hyman B, Justice J. Introduction to ophthalmoscopy. 4th ed. Upjohn: Michigan; 1996.

Ahuja M. Ophthalmology Handbook. 1st ed. India Binding House: Delhi; 2003.

Mehra V, Minassian DC. A rapid method of grading cataract in epidemiological studies and eye surveys. Br J Ophthalmol 1998;72:801-3.

Chitra V, Lakshamib KS, Sharmaa S, Patidara A, Rajeshb T. Lisinopril attenuates selenite-induced experimental cataract development: an in vitro study. Int J Pharm Pharm Sci 2009;1:17-23.

Ito Y, Nabekura T, Takeda M, Nakao M, Terao M, Hori R, et al. Nitric oxide participates in cataract development in selenite-treated rats. Curr Eye Res 2001;22:215-20.

Ohkawa H, Ohishi N, Yagi K. Assay of lipid peroxide in animal tissue by thiobarbituric acid reaction. Anal Biochem 1997;95:351-7.

Shearer TR, Hong M, Fukiage K, Azuma M. Selenite nuclear cataract: a review of the model. Mol Vision 1997;3:8:651-722.

Chung LK, Ching KC, Hsu WM. Nitric oxide levels in the aqueous humor in cataract patients. J Cataract Refractive Surg 2002;28:507-12.

MARS JA. High-dose antioxidant supplementation and cataract risk. Nutr Rev 2004;62:28-32.

Li Yan, Liu Ya-Zhen, Shi Jing-Ming, Jia Song-Bai. Alpha-lipoic acid protects the lens from H2O2-induced cataract by inhibiting. Asian Pacific J Trop Med 2013;6:558-1.

Kernt M, Hirneiss C, Neubauer SA, Ulbig MW, Kampik A. Coenzyme Q10 prevents human lens epithelial cells from light-induced apoptotic cell death by reducing oxidative stress and stabilizing BAX⁄Bcl-2 ratio. Acta Ophthalmol 2010;88:e78–e86.

Crane Frederick L. Biochemical functions of coenzyme Q10. J Am College Nutr 2001;20:591-8.




About this article

Title

THE ANTI-CATARACT EFFECT OF COENZYME Q10 IN RABBITS

Keywords

Cataractogenesis, Oxidative stress, Coenzyme Q10

DOI

10.22159/ijpps.2017v9i3.11391

Date

03-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 3, 2017 Page: 13-16

Online ISSN

0975-1491

Statistics

153 Views | 334 Downloads

Authors & Affiliations

Baha'a A. Abdul Hussein
Head of Dept. of Pharmacology, College of Veterinary Medicine, University of Al-Qadissiya, Al-Qadissiya Iraq, PhD Student in Pharmacology, College of Medicine, Al-Mustansiriyah University, Baghdad-Iraq
Iraq

Ahmed Salim Mahmood
Head of Dept. of Pharmacology, College of Veterinary Medicine, University of Al-Qadissiya, Al-Qadissiya Iraq, PhD Student in Pharmacology, College of Medicine, Al-Mustansiriyah University, Baghdad-Iraq
Iraq


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