STUDY TO EVALUATE THE ROLE OF SEROTONIN IN PARKINSONIAN SYMPTOMS
Keywords:Haloperidol, olanzapine, dopamine, serotonin subreceptor, extra pyramidal symptoms, Parkinsonism
Objective: Study to evaluate the role of serotonin in Parkinsonism by using olanzapine (an atypical antipsychotic drug) on haloperidol-induced extrapyramidal symptoms (EPS) in Swiss albino mice.
Methods: EPS like catatonia and rigidity were produced in Swiss albino mice by intraperitoneal (i. p) injection of haloperidol. Olanzapine was given as a pretreatment for acute and sub-acute basis (15 d orally) and effects were compared in terms of protection against catatonia like abnormal movements. They were analyzed statistically by ANOVA followed by post hoc Tukey's test using SPSS 20 software.
Results: There was no improvement in catatonia scores on the acute study, but on subacute (15 d) intervention a moderate improvement in the combination group (15-20 %) was seen as compared to haloperidol alone.
Conclusion: Low-dose olanzapine due to serotonin antagonism and probable partial D1 agonist actions may have the potential to improve the features of Parkinsonism. Further, it can have advantages over selective serotonin reuptake inhibitors (SSRI) for antidepressant activity in above disease.
Keywords: Haloperidol, Dopamine receptor subtypes (D1 and D2), Serotonin receptor subtypes (5HT1-7), EPS, Parkinsonism Disease (PD)
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