IN VITRO AND OMICS TECHNOLOGIES OPENS A NEW AVENUE FOR DECIPHERING WITHANOLIDE METABOLISM IN WITHANIA SOMNIFERA

Authors

  • Pankajavalli Thirugnanasambantham
  • Kalaiselvi Senthil Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641043, Tamil Nadu, India http://orcid.org/0000-0002-8276-4607

Keywords:

Withania somnifera, Withanolides, in vitro cultures, Genomics, Transcriptomics, In silico, Proteomics, Metabolomics

Abstract

Withania somnifera, commonly known as Ashwagandha or winter cherry, is a principal medicinal plant that has been used in Ayurvedic and native medicine. In view of its varied therapeutic prospective, it has also been the subject of considerable modern scientific attention. Ashwagandha roots are an integral of over 200 formulations in Ayurveda, Siddha and Unani medicine, which are used in the treatment of various physiological disorders. The major chemical constituents of this plant, the withanolides, are a group of naturally occurring C28-steroidal lactones. It has been extensively investigated in terms of chemistry and bioactivity profiling. However, there exists only very little fragmentary evidence about the dynamics of withanolide biosynthesis. This review examines different in vitro approaches that had been carried out over past decade of years and newly developed omics technologies for the large scale production of withanolides as well as for the analysis of genes associated with withanolide biosynthesis.

Keywords: Withania somnifera, Withanolides, in vitro cultures, Genomics, Transcriptomics, In silico, Proteomics, Metabolomics.

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Senthil K, Pankajavalli T, Oh TJ, Kim SH, Choi HK. Free radical scavenging activity and comparative metabolic profiling of in vitro cultured and field grown Withania somnifera roots. PLoS one 2015;4:e0123360. Doi:10.1371/journal.pone.0123360. [Article in Press]

Thirugnanasambantham P, Senthil K, Oh TJ, Coi HK. Comparative chemometric profiles between leaf tissues of Withania somnifera Cultured in vitro and field. Int J Pharm Pharm Sci 2015;7:66-71.

Published

01-07-2016

How to Cite

Thirugnanasambantham, P., and K. Senthil. “IN VITRO AND OMICS TECHNOLOGIES OPENS A NEW AVENUE FOR DECIPHERING WITHANOLIDE METABOLISM IN WITHANIA SOMNIFERA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 7, July 2016, pp. 17-26, https://innovareacademics.in/journals/index.php/ijpps/article/view/11732.

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Review Article(s)