STUDIES ON DEVELOPMENT OF SUSTAINED RELEASE DILTIAZEM HYDROCHLORIDE MATRICES THROUGH JACKFRUIT MUCILAGE

  • M.a. Shende Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati
  • R. P. Marathe Department of Pharmaceutical Chemistry, Government College of Pharmacy, Kathora Naka, Amravati 444604, India.
  • S. B. Khetmalas Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati. 444604, India.
  • P. N. Dhabale Department of Pharmaceutical Chemistry, Government College of Pharmacy, Kathora Naka, Amravati 444604, India.

Abstract

Objective: The sustained release of drug from dosage form is useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of the present work was to develop sustained release diltiazem hydrochloride matrix tablets using natural polymers and gums like jackfruit mucilage and tamarind polysaccharide.

Methods: Tablets were prepared by direct compression method and evaluated for various physical parameters. Direct compression method using response surface methodology, followed by optimization of the evaluation parameters were employed to get final optimized formulation.

Results: Among all formulations, M2 shows 92.87% better controlled release at the end of 12 hrs. The release co-efficient values ‘n’ (>0.5) indicated that the drug release followed non fickian anomalous mechanism based on formulation factors. The stability studies were carried out according to ICH guideline which indicates that the selected formulation was stable.

Conclusion: Diltiazem HCl matrices could be developed with desirable release modulation for a once daily administration.

Keywords: Diltiazem HCl (DLT), Jackfruit mucilage, Tamarind seeds, Matrics 

Keywords: Diltiazem HCl (DLT), Jackfruit mucilage, Tamarind seeds, Matrics

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Author Biography

M.a. Shende, Department of Pharmaceutics, Government College of Pharmacy, Kathora Naka, Amravati

Department of Pharmaceutics

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How to Cite
Shende, M., R. Marathe, S. Khetmalas, and P. Dhabale. “STUDIES ON DEVELOPMENT OF SUSTAINED RELEASE DILTIAZEM HYDROCHLORIDE MATRICES THROUGH JACKFRUIT MUCILAGE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 7, July 2014, pp. 72-78, https://innovareacademics.in/journals/index.php/ijpps/article/view/1203.
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Original Article(s)