STUDIES ON DEVELOPMENT OF SUSTAINED RELEASE DILTIAZEM HYDROCHLORIDE MATRICES THROUGH JACKFRUIT MUCILAGE
Objective: The sustained release of drug from dosage form is useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of the present work was to develop sustained release diltiazem hydrochloride matrix tablets using natural polymers and gums like jackfruit mucilage and tamarind polysaccharide.
Methods: Tablets were prepared by direct compression method and evaluated for various physical parameters. Direct compression method using response surface methodology, followed by optimization of the evaluation parameters were employed to get final optimized formulation.
Results: Among all formulations, M2 shows 92.87% better controlled release at the end of 12 hrs. The release co-efficient values â€˜nâ€™ (>0.5) indicated that the drug release followed non fickian anomalous mechanism based on formulation factors. The stability studies were carried out according to ICH guideline which indicates that the selected formulation was stable.
Conclusion: Diltiazem HCl matrices could be developed with desirable release modulation for a once daily administration.
Keywords: Diltiazem HCl (DLT), Jackfruit mucilage, Tamarind seeds, MatricsÂ
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