XYLAZINE-KETAMINE ANAESTHESIA; COMPARATIVE STUDIES IN MALE AND FEMALE CANE RATS (THRYONOMYS SWINDERIANUS)


Olatunji-akioye A, Ojiaka H N, Samuel E. S

Abstract


Objective: Domestication of the Cane rats is on-going globally and might replace the conventional rodents used in biomedical research in future. However, the paucity of information on adequate anaesthesia vis-a-vis xylazine-ketamine drug combination in the male and female Cane rats warranted this study.

Methods: Six adult Cane rats {1.8±0.7 kg body weights (bwt.)} assigned into group A (Female) and group B (Male) of three rats each was used for the study. Each animal was premedicated with atropine sulphate (0.05 mg/kg bwt), and later administered xylazine (10 mg/kg bwt) and ketamine (100 mg/kg bwt) intramuscularly. Meanwhile, anaesthetic characteristics and physiologic indices of anaesthesia were monitored.

Results: Results obtained showed that the physiologic indices; open eyelids, smooth induction and recovery, skeletal muscle relaxation and somatic analgesia were observed in all the animals, however, the anaesthetic indices; time to induction, time to standing, duration of analgesia and duration of recumbency showed marked sex variations. The mean values for the duration of analgesia and recumbency were significantly elevated (P<0.05) in group B as compared with group A. Similar trend was seen for time to standing, but, it was non-significant (P>005). However, time to induction mean value for group A was non-significantly increased (P>005) when compared with group B. The heart rate, respiratory rate and rectal temperature mean values decreased in both groups non-significantly (P>0.05).

Conclusion: Conclusively, the xylazine-ketamine combination produced anaesthesia in Cane rat and the combination is more tolerated in the male Cane rats than the female Cane rats.


Keywords


African Cane rats, Xylaxine, Ketamine, Anaesthesia

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About this article

Title

XYLAZINE-KETAMINE ANAESTHESIA; COMPARATIVE STUDIES IN MALE AND FEMALE CANE RATS (THRYONOMYS SWINDERIANUS)

Keywords

African Cane rats, Xylaxine, Ketamine, Anaesthesia

DOI

10.22159/ijpps.2017v9i1.12140

Date

31-12-2016

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 1, 2017 Page: 52-55

Online ISSN

0975-1491

Statistics

37 Views | 47 Downloads

Authors & Affiliations

Olatunji-akioye A
Department of Veterinary Reproduction and Surgery, University of Ibadan, Ibadan, Nigeria
Nigeria

Ojiaka H N
Department of Veterinary Reproduction and Surgery, University of Ibadan, Ibadan, Nigeria
Nigeria

Samuel E. S
Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Ibadan, Nigeria
Nigeria


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