A COMPARATIVE STUDY ON THE EFFECTIVENESS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACEIs) AND ANGIOTENSIN RECEPTOR BLOCKERS (ARBs) IN DIABETIC NEPHROPATHY IN TYPE 2 DIABETES MELLITUS PATIENTS


N. Senthilkumar, Anandhasayanam A., Mohammed Safil K., Shemimol S.

Abstract


Objective: To observe the clinical outcomes on usage of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in type 2 diabetic nephropathy patients.

Methods: A total 70 patients diagnosed with diabetic nephropathy were treated with ACEIs or ARBs were enrolled in this study. The data was collected from the out patients and the physician. A data collection form was used for collecting patient data. The form was used to record the details of patient’s demographics, history of diabetes mellitus, duration of diabetes mellitus co morbidities, food habits and laboratory parameters such as serum creatinine, HbA1c and all the relevant things. The study has obtained ethical clearance from the institution ethics committee (IEC).

Results: The study showed middle aged patients were more prone to diabetes and pre-existing hypertension is a major risk factor for diabetic nephropathy. Majority of the patients had long duration of diabetes mellitus which indicates the strong relation between duration of diabetes mellitus with diabetic nephropathy. Compared to ACE inhibitors, ARBs decreased the level of renal parameters. This reveals the better reno-protective effect of ARBs over ACE inhibitors. ARBs had more beneficial effects in reducing the major risk factor like proteinuria in diabetic nephropathy. A considerable reduction in HbA1c values were also observed in patients using ARBs.

Conclusion: While comparing the improvement in proteinuria and the laboratory outcomes, ARBs were beneficial relatively to the ACEs in patients with diabetic nephropathy.

 


Keywords


Diabetic nephropathy, Angiotensin Converting enzyme, Angiotensin Receptor blockers

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About this article

Title

A COMPARATIVE STUDY ON THE EFFECTIVENESS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACEIs) AND ANGIOTENSIN RECEPTOR BLOCKERS (ARBs) IN DIABETIC NEPHROPATHY IN TYPE 2 DIABETES MELLITUS PATIENTS

Keywords

Diabetic nephropathy, Angiotensin Converting enzyme, Angiotensin Receptor blockers

Date

01-06-2016

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 8, Issue 8, 2016 Page: 289-292

Online ISSN

0975-1491

Statistics

68 Views | 59 Downloads

Authors & Affiliations

N. Senthilkumar
Principal, JKKMMRFs AJKK SA College of Pharmacy, Ethirmedu, B Komarapalayam 638183, Tamilnadu, India
India

Anandhasayanam A.

Mohammed Safil K.

Shemimol S.


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