SYNTHETIC PRODUCT ILLEGALLY SOLD IN BRAZIL AS A MEDICINAL HERBAL PRODUCT: CHEMICAL ANALYSIS AND THE PATIENTS MEDICATION EXPERIENCE

Authors

  • Thays Santos Mendonca Campus Centro Oeste Dona Lindu, Universidade Federal De São João Del Rei, Brazil
  • Rayza Martins Miranda Campus Centro Oeste Dona Lindu, Universidade Federal De São João Del Rei, Brazil
  • Carlos Alexandre Carollo Laboratório de Produtos Naturais e Espectrometria de Massas, Universidade Federal de Mato Grosso do Sul, Brazil
  • Simone De Araujo Medina Mendonca Departmento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Brazil
  • JOAO MAXIMO DE SIQUEIRA Campus Centro Oeste Dona Lindu, Universidade Federal De São João Del Rei, Brazil

DOI:

https://doi.org/10.22159/ijpps.2016v8i10.13160

Keywords:

Herbal medicine adulteration, Chemical analysis, Medication experience, Qualitative research

Abstract

Objective: To analyze a product illegally sold as herbal medicine acquired and used by a patient and to understand the reasons that led the patient to use this product. Methods: The chemical analysis was performed by thin layer chromatography (TLC) and mass spectrometry (MS) analysis with a direct infusion with a Bruker Daltonics UltroTOF-Q, in positive mode. A qualitative interview was conducted with the patient. The data obtained were submitted to thematic analysis. Results: Chemical analysis confirmed the presence of piroxicam and orphenadrine, and the complete absence of a natural product. The qualitative study revealed three themes: previous experience with the disease and the use of medicines, feelings about the care provided by health professionals, and the patient's solution.

Conclusion: The commercial availability of this kind of product raises concerns about safety and demonstrates the necessity for more intensive surveillance by health authorities. In addition, the present study showed the need for a patient-centered practice and the understanding of medication experience to provide effective care to patients who use medicines to preserve them from unsafe products.

Downloads

Download data is not yet available.

References

Ngugi MP, Njagi MJ, Kibiti MC, Ngeranwa JNJ, Njagi NME, Njue MW, et al. Herbal management of diabetes mellitus: a rapidly expanding research avenue. Int J Curr Pharm Res 2012;4:1-4.

Mani R, Kunchu K, Pallab KH. The role of herbal plants in the diabetes mellitus therapy: an overview. Int J Appl Pharm 2014;6:1-3.

Marmitt DJ, Bitencourt S, Silva AC, Goettert MI, Rempel C. Medicinal plants of ReniSUS with analgesic activity. J Crit Rev 2016;3:1-4.

Ranade SY, Gaud RS. Current strategies in herbal drug delivery for arthritis: an overview. Int J Pharm Sci Res 2013;4:3782-94.

Moritz MIG, Lang KL, Baratto L, Caro MSB, Falkenberg M, Schenkel EP. Identification of undeclared synthetic drugs in herbal products commercialized in Brazil: The Indiano Talun†case. Acta Farm Bonaerense 2008;27:274-9.

Hamburger M, Hostettmann K. Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry 1991;30:3864–74.

Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z. Medicinal plants in therapy. Bull WHO 1985;63:965-81.

Shoemaker SJ, Ramalho-de-Oliveira D. Understanding the meaning of medications for patients: the medication experience. Pharm World Sci 2007;30:86-91.

Shoemaker SJ, Ramalho-de-Oliveira D, Alves M, Ekstrand M. Patient education and counseling the medication experience: preliminary evidence of its value for patient education and counseling on chronic medications. Patient Education Counseling 2011;83:443-50.

Wolf JA, Niederhauser V, Marshburn D, LaVela SL. Defining patient experience. Patient Exp J 2014;1:7-19.

Ernst E. Adulteration of Chinese herbal medicines with synthetic drugs : a systematic review. J Intern Med 2002;252:107-13.

Lanini J, Duarte-almeida JM, Nappo S, Carlini EA. O que vêm da terra não faz mal-relatos de problemas relacionados ao uso de plantas medicinais por raizeiros de Diadema/SP. Braz J Pharmacog 2009;19:121-9.

Elvin-Lewis M. Should we be concerned about herbal remedies. J Ethnopharmacol 2001;75:141-64.

Konkimalla VB, Efferth T. Evidence-based Chinese medicine for cancer therapy. J Ethnopharmacol 2010;116:207-10.

Podder AK, Chakrobarty JK, Faroque ABM. Qualitative and quantitative analysis of sildenafil in traditional medicines and dietary supplements. Asian J Pharm Clin Res 2014;7:25-30.

Wagner H, Bladt S. Plant Drug Analysis: A Thin Layer Chromatography Atlas. 2nd ed. Berlin; 2001.

Pope C, Ziebland S, Mays N. Analysing qualitative data. Br Med J 2000;320:114-6.

Cornish F, Gillespie A, Zittoun T. Collaborative analysis of qualitative data. In: Flick U. The sage Handbook of Qualitative Data Analysis; 2013. p. 79-93.

Mncwangi N, Chen W, Vermaak I, Viljoen AM, Gericke N. Devil’s claw: a review of the etnobotany, phytochemistry and biological activity of harpagophytum procumbens. J Ethnopharmacol 2012;143:755-71.

Jena M, Mishra S, Pradhan S, Jena S, Mishra SS. Chronic pain, its management and psychological issues: a review. Asian J Pharm Clin Res 2015;8:42-7.

Ramalho-de-Oliveira D, Shoemaker SJ, Ekstrand M, Alves MR. Preventing and resolving drug therapy problems by understanding patient's medication experiences. J Am Pharm Assoc 2012;52:71-80.

Toye F, Seers K, Allcock N, Briggs M, Carr E, Andrews J, et al. Patients’ experiences of chronic non-malignant musculoskeletal pain : a qualitative systematic review. Br J General Practice 2013;63:829-41.

Mohammed MA, Moles RJ, Chen TF. Medication-related burden and patients’ lived experience with medicine: a systematic review and meta synthesis of qualitative studies. B Med J Open 2016;6:1-16.

Bensing J. Bridging the gap. The separate worlds of evidence-based medicine and patient-centered medicine. Patient Educ Couns 2000;39:17–25.

Published

01-10-2016

How to Cite

Mendonca, T. S., R. M. Miranda, C. A. Carollo, S. D. A. M. Mendonca, and J. M. DE SIQUEIRA. “SYNTHETIC PRODUCT ILLEGALLY SOLD IN BRAZIL AS A MEDICINAL HERBAL PRODUCT: CHEMICAL ANALYSIS AND THE PATIENTS MEDICATION EXPERIENCE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 8, no. 10, Oct. 2016, pp. 134-7, doi:10.22159/ijpps.2016v8i10.13160.

Issue

Section

Original Article(s)

Most read articles by the same author(s)