• Valerie Sastre School of Pharmacy, University of Puerto Rico, P.O. Box 365067, San Juan, P.R 00936
  • Evone S. Ghaly School of Pharmacy, University of Puerto Rico, P.O. Box 365067, San Juan, P.R 00936


Ibuprofen, Lipid matrix, Solid state, Kinetic release model, Lipid-surfactant nanoparticles, Controlled release


Objectives: The effect of lipid phase composition, concentration of lipid and surfactant on the entrapment, morphology, particle size and release profiles of ibuprofen-loaded lipid particles was evaluated.

Methods: Formulations containing only a solid lipid (Compritol® 888 ATO) and formulations containing mixture of solid and liquid lipids (Compritol® 888 ATO: Labrafil® M 1944 CS) were prepared at various lipid level (5%, 10% and 15% w/v) and surfactant (1.35% and 3%w/v) concentrations using the hot homogenization method.

Results: The particle size distribution was found to be polydisperse with a high concentration of microparticles. The particles were spherical in shape. The preparation method was effective in producing particles with high drug entrapment efficiencies (65% – 100%). Drug release studies showed a controlled release profile that follow diffusion kinetic model for all formulations. High lipid concentrations (10% and 15%) increased drug entrapment capacity and showed low initial burst of the drug during early time of testing dissolution. X-Ray diffraction and NMR studies showed coexistence of both amorphous and crystalline forms of the ibuprofen within the lipid matrix. Addition of Labrafil® led to a more amorphous internal structure by modifying the crystallinity of both ibuprofen and the lipid Compritol®.

Conclusions: This investigation solved problems associated with nanoparticles


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Author Biography

Valerie Sastre, School of Pharmacy, University of Puerto Rico, P.O. Box 365067, San Juan, P.R 00936

Graduate Student


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How to Cite

Sastre, V., and E. S. Ghaly. “CONTROLLED RELEASE IBUPROFEN NANOPARTICLES: PHYSICO-CHEMICAL CHARACTERIZATION AND DRUG RELEASE”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 99-107,



Original Article(s)