POLYMERIC MATERIALS AS PLATFORMS FOR TOPICAL DRUG DELIVERY: A REVIEW


Siew Yong Teo, Siang Yin Lee, Michael J. Rathbone, Seng Neon Gan

Abstract


With the emergence of novel and more effective drug therapies, increased importance is being placed upon the drug delivery technology. Topical formulations are attractive alternatives to oral formulations and offer several advantages, such as avoiding first-pass hepatic metabolism and gastric degradation. The major obstacle to drug delivery across the skin (transdermal) is the barrier nature of the skin which limits permeation of molecules. A wide range of polymeric materials is currently available for drug delivery to and across the skin. The synthetic polymers such as polyesters, polyamides, polyurethanes, polyanhydrides and poly(ortho-esters) display advantages of reproducibility of synthesis, a range of material properties and biodegradability, whereas agro-polymers like polysaccharides, proteins and lipids have already shown great promise in terms of type of material, range of properties, processing technique and biocompatibility. This review article summarizes features of different polymers and their potential applications in topical drug delivery system.

Keywords


Topical delivery; polyester; polyamide; polyurethane; polyanhydride; agro-polymer; polysaccharide; protein; lipid

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About this article

Title

POLYMERIC MATERIALS AS PLATFORMS FOR TOPICAL DRUG DELIVERY: A REVIEW

Keywords

Topical delivery; polyester; polyamide; polyurethane; polyanhydride; agro-polymer; polysaccharide; protein; lipid

Date

31-12-2016

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 1, 2017 Page: 14-20

Online ISSN

0975-1491

Statistics

155 Views | 107 Downloads

Authors & Affiliations

Siew Yong Teo
School of Postgraduate Studies and Research, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
Malaysia

Siang Yin Lee
School of Pharmacy, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000 Kuala Lumpur, Malaysia
Malaysia

Michael J. Rathbone
ULTI Pharmaceuticals, 19 Pembroke Street, Hamilton Lake, Hamilton, 3204, New Zealand
New Zealand

Seng Neon Gan
Faculty of Science, University of Malaya, Lembah Pantai, 50603 Kuala Lumpur, Malaysia
Malaysia


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