A REVIEW ON ANTI-HCV AGENTS TARGETING ACTIVE SITE AND ALLOSTERIC SITES OF NON-STRUCTURAL PROTEIN 5B [NS5B]


Prasanthi Polamreddy, Vinita Vishwakarma, Rambabu Gundla

Abstract


Hepatitis C, a chronic disease affecting the global population significantly is caused majorly by Hepatitis C virus [HCV]. Among the several druggable targets explored for Hepatitis C, the viral protein, non-structural protein 5B [NS5B] is the target of choice for researchers as it is the key enzyme in the HCV replication and its active site is conserved among all genotypes. In the recent years the landscape of Hepatitis C therapies, have evolved from Peg-Interferon [PEG-INF]/Ribavirin, to directly acting anti-virus along with PEG-INF and finally, INF free regimens with greater than 90% sustained virological response [SVR]. The launch of Sofosbuvir, a nucleotide inhibitor of NS5B marks the major paradigm in hepatitis C research. Sofosbuvir exhibits, pan-genotypic activity, low barrier to resistance, highly effective and safe. However, the high prices of these medications limit their universal access. This review will focus on progress towards the discovery and development of NS5B inhibitors targeting allosteric sites and active site, covering the chemical class and structure-activity relationships.


Keywords


Hepatitis C virus, NS5B, Inhibitors, Structure-Activity relationships, Genotypic variance, Allosteric site, Active site

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About this article

Title

A REVIEW ON ANTI-HCV AGENTS TARGETING ACTIVE SITE AND ALLOSTERIC SITES OF NON-STRUCTURAL PROTEIN 5B [NS5B]

Keywords

Hepatitis C virus, NS5B, Inhibitors, Structure-Activity relationships, Genotypic variance, Allosteric site, Active site

DOI

10.22159/ijpps.2016v8i11.13965

Date

28-10-2016

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 8, Issue 11, 2016 Page: 1-18

Online ISSN

0975-1491

Statistics

228 Views | 654 Downloads

Authors & Affiliations

Prasanthi Polamreddy
Centre for Nanoscience and Nanotechnology, Sathyabama University, Jeppiaar Nagar, Old Mahabalipuram Road, Chennai-600 119, India
India

Vinita Vishwakarma
Centre for Nanoscience and Nanotechnology, Sathyabama University, Jeppiaar Nagar, Old Mahabalipuram Road, Chennai-600 119, India
India

Rambabu Gundla
Department of Chemistry, GITAM School of Technology, HTP Campus, GITAM University, Hyderabad 502329, TS, India


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