A STUDY OF THE HYPOLIPIDEMIC AND ANTIOXIDANT ACTIVITIES OF WHOLE PLANT EXTRACTS OF IPOMOEA AQUATICA FORK IN EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN RABBITS


Aziz Sahid, Gohain Kalpana

Abstract


Objective: The aim of the study has been to investigate the possible hypolipidemic and antioxidant properties of the whole plant extract of Ipomoea aquatica in experimentally induced hyperlipidemia in rabbits.

Methods: Ethanolic extract of I. aquatica whole plant (EEIAWP) was prepared by percolation method. The extract was evaluated for hypolipidemic and antioxidant activities using 400 mg/kg body weight per day in a high fat diet induced hyperlipidemia in rabbits. The results were analyzed using one-way analysis of variance (ANOVA) followed by Bonferroni’s multiple comparison tests and compared to the normal control, experimental control and the standard drug (atorvastatin 2.1 mg/kg body weight per day) groups. The results were expressed as mean±standard error of mean (SEM). Values with p<0.05 were considered significant.

Results: Oral administration of EEIAWP in the test group showed a significant reduction in the serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and a significant increase in the high-density lipoprotein cholesterol (HDL-C) when compared to the experimental control group. There were also significantly elevated catalase and superoxide dismutase (SOD) activities and significantly lower malondialdehyde (MDA) levels in the test group compared to the experimental group. Similar results were also found in the standard drug group.

Conclusion: The results of our experiment demonstrated that EEIAWP possesses significant antihyperlipidemic and antioxidant activities and hence could be a potential source of medication as an adjuvant to the existing therapy for treatment of dyslipidemia.


Keywords


Ipomoea aquatica, Hypolipidemic, Antioxidant property

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About this article

Title

A STUDY OF THE HYPOLIPIDEMIC AND ANTIOXIDANT ACTIVITIES OF WHOLE PLANT EXTRACTS OF IPOMOEA AQUATICA FORK IN EXPERIMENTALLY INDUCED HYPERLIPIDEMIA IN RABBITS

Keywords

Ipomoea aquatica, Hypolipidemic, Antioxidant property

DOI

10.22159/ijpps.2016v8i10.14059

Date

23-08-2016

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 8, Issue 10, 2016 Page: 265-269

Online ISSN

0975-1491

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172 Views | 81 Downloads

Authors & Affiliations

Aziz Sahid
Department of Pharmacology, Assam Medical College, Dibrugarh, Assam
India

Gohain Kalpana
Department of Pharmacology, Assam Medical College, Dibrugarh, Assam
India


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