IN-VIVO ANTI-INFLAMMATORY ACTIVITIES OF ETHANOLIC ROOT EXTRACT OF BAUHINIA VARIEGATA LINN

Authors

  • P.MEENA PRABHA Department of pharmacognosy, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183 Namakkal (Dt), Tamilnadu, India
  • V. KAMALAKKANNAN Department of pharmaceutics, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183 Namakkal (Dt), Tamilnadu, India
  • K.S.G.arul Kumaran Department of pharmaceutics (H.O.D), K.M.C.H college of Pharmacy, Coimbatore-641048, Tamil nadu, India
  • R. SAMBATHKUMAR Department of pharmaceutics(H.O.D), J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183 Namakkal (Dt), Tamilnadu, India

Keywords:

Anti-inflammatory activities, BVEE- Bauhinia variegata ethanolic extract, Carrageenan induced paw edema, Cotton pellet induced granuloma method

Abstract

Objective: The objective of present study was to evaluate the anti-inflammatory activity of ethanolic extract of Bauhinia variegate root.

Methods: In the present study BVEE at 200 and 400 mg/kg body weight was studied for anti-inflammatory activities in different animal models.. Anti- inflammatory activity was carried out by using carrageenan induced paw edema model and cotton pellet induced granuloma model in wistar rats.

Results: The results shows that BVEE possess anti-inflammatory activity in acute as well as sub acute models of inflammation in rats. BVEE (200 and 400 mg/kg) showed significant (p <0.01) anti-inflammatory activity by reducing the paw edema volume in carrageenan-induced paw edema in rats in the late phase (2to4h)regulated by prostaglandins and leucotrienes and in cotton pellet induced granuloma model BVEE decreased dry weight of granuloma.

Conclusion: The observed pharmacological activity may be due to presence of phytochemical compounds present in the extract like alkaloids, flavonoids, phenols, saponins and tannins.

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Author Biographies

P.MEENA PRABHA, Department of pharmacognosy, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183 Namakkal (Dt), Tamilnadu, India

Department of Pharmacognosy

V. KAMALAKKANNAN, Department of pharmaceutics, J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183 Namakkal (Dt), Tamilnadu, India

Department of Pharmaceutics

K.S.G.arul Kumaran, Department of pharmaceutics (H.O.D), K.M.C.H college of Pharmacy, Coimbatore-641048, Tamil nadu, India

Department of Pharmaceutics

R. SAMBATHKUMAR, Department of pharmaceutics(H.O.D), J.K.K. Nattraja College of Pharmacy, Kumarapalayam-638183 Namakkal (Dt), Tamilnadu, India

Department of pharmaceutics

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Published

31-08-2014

How to Cite

PRABHA, P. ., V. KAMALAKKANNAN, K. Kumaran, and R. SAMBATHKUMAR. “IN-VIVO ANTI-INFLAMMATORY ACTIVITIES OF ETHANOLIC ROOT EXTRACT OF BAUHINIA VARIEGATA LINN”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 6, no. 8, Aug. 2014, pp. 445-8, https://innovareacademics.in/journals/index.php/ijpps/article/view/1531.

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