POLYMERIC NANOPARTICLES FOR IMPROVED BIOAVAILABILITY OF CILNIDIPINE


Rohit Mishra, Showkat R. Mir, Saima Amin

Abstract


Objective: In the present study, we aimed to optimize, characterize and evaluate poly lactic-glycolic acid nanoparticles of cilnidipine for improved permeation across the gastrointestinal tract.

Methods: Poly lactic-glycolic acid-cilnidipine (PLGA-CIL) nanoparticles were prepared by an emulsification solvent evaporation/diffusion method using polyvinyl alcohol (PVA) as a surfactant. The prepared nanoparticles were successfully characterized for particle size, shape, drug release and pharmacological effect.

Results: Polymeric nanoparticles of cilnidipine at a dose of 10 mg had a small particle size of 272 nm with smooth morphology. Nearly 81% of the drug was encapsulated in the polymeric structure and showed 18.99±0.59% of release at pH 1.2 within 3h, however, at pH 6.8 the release was 80.89±1.59%. The formulation had a better antihypertensive effect on methylprednisolone-induced hypertensive rats. The relative bioavailability of the nanoparticles was found to be 2.44 and 2.94 fold higher than the tablet and drug suspension respectively.

Conclusion: The results demonstrated that the novel delivery system offers an effective strategy for treatment of hypertension.


Keywords


Polymeric nanoparticles, Bioavailability, Solvent evaporation, Polymers

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About this article

Title

POLYMERIC NANOPARTICLES FOR IMPROVED BIOAVAILABILITY OF CILNIDIPINE

Keywords

Polymeric nanoparticles, Bioavailability, Solvent evaporation, Polymers

DOI

10.22159/ijpps.2017v9i4.15786

Date

27-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 4, 2017 Page: 129-139

Online ISSN

0975-1491

Statistics

14 Views | 56 Downloads

Authors & Affiliations

Rohit Mishra
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062
India

Showkat R. Mir
2Phytopharmaceutical Laboratory, Department of Pharmacognosy and phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062
India

Saima Amin
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062
India

 

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