• Rohit Mishra Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062
  • Showkat R. Mir 2Phytopharmaceutical Laboratory, Department of Pharmacognosy and phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062
  • Saima Amin Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062


Objective: In the present study, we aimed to optimize, characterize and evaluate poly lactic-glycolic acid nanoparticles of cilnidipine for improved permeation across the gastrointestinal tract.

Methods: Poly lactic-glycolic acid-cilnidipine (PLGA-CIL) nanoparticles were prepared by an emulsification solvent evaporation/diffusion method using polyvinyl alcohol (PVA) as a surfactant. The prepared nanoparticles were successfully characterized for particle size, shape, drug release and pharmacological effect.

Results: Polymeric nanoparticles of cilnidipine at a dose of 10 mg had a small particle size of 272 nm with smooth morphology. Nearly 81% of the drug was encapsulated in the polymeric structure and showed 18.99±0.59% of release at pH 1.2 within 3h, however, at pH 6.8 the release was 80.89±1.59%. The formulation had a better antihypertensive effect on methylprednisolone-induced hypertensive rats. The relative bioavailability of the nanoparticles was found to be 2.44 and 2.94 fold higher than the tablet and drug suspension respectively.

Conclusion: The results demonstrated that the novel delivery system offers an effective strategy for treatment of hypertension.

Keywords: Polymeric nanoparticles, Bioavailability, Solvent evaporation, Polymers


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How to Cite
Mishra, R., S. R. Mir, and S. Amin. “POLYMERIC NANOPARTICLES FOR IMPROVED BIOAVAILABILITY OF CILNIDIPINE”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 9, no. 4, Feb. 2017, pp. 129-3, doi:10.22159/ijpps.2017v9i4.15786.
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