KARYOTYPIC ANALYSIS OF CHROMOSOMAL POLYMORPHISM IN RELATION TO REPRODUCTIVE FAILURE


Ketan K. Vaghasia, Nidhi D. Shah, Parth S. Shah, Vidhi M. Bhatt, Sandip C. Shah, Mandava V. Rao

Abstract


Objective: This study was undertaken to elucidate the role of heteromorphism in causation of reproductive anomalies like infertility.

Methods: In our study, cytogenetic analysis of 830 suspected referral cases of both sexes were assessed using standard karyotypic technique with Giemsa staining from their blood samples. We identified heteromorphism of D/G groups and non-acrocentric chromosomes following WHO nomenclature.

Results: Our data revealed that most of our heteromorphic cases (38;4.58%) were related to p arm satellites (ps+) of the chromosomes and are related to infertility and abortion. No significant gender variation was noticed in this study.

Conclusion: We hence, suggest that heteromorphism is associated with a loss of reproductive function, as heterochromatin may contain genes that regulate cellular roles in reproduction. Further, it becomes important that such cases are considered for molecular studies, genetic counseling and prenatal/pre-implantation screening.


Keywords


Chromosomal Polymorphism, Reproductive Failure, Cytogenetic Analysis. Acrocentric and non-acrocentric groups, Heterochromatin

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About this article

Title

KARYOTYPIC ANALYSIS OF CHROMOSOMAL POLYMORPHISM IN RELATION TO REPRODUCTIVE FAILURE

Keywords

Chromosomal Polymorphism, Reproductive Failure, Cytogenetic Analysis. Acrocentric and non-acrocentric groups, Heterochromatin

DOI

10.22159/ijpps.2017v9i4.15787

Date

27-02-2017

Additional Links

Manuscript Submission

Journal

International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 4, 2017 Page: 140-143

Online ISSN

0975-1491

Statistics

108 Views | 227 Downloads

Authors & Affiliations

Ketan K. Vaghasia
Supratech Micropath Laboratory and Research Institute
India

Nidhi D. Shah
Supratech Micropath Laboratory and Research Institute
United States

Parth S. Shah
Supratech Micropath Laboratory and Research Institute
United States

Vidhi M. Bhatt
Supratech Micropath Laboratory and Research Institute
India

Sandip C. Shah
Supratech Micropath Laboratory and Research Institute
India

Mandava V. Rao
Ex. Director, School of Sciences, Gujarat University, Ahmedabad, Gujarat India


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