C. S. Brethis, S. Thamizharasan, S. A. Sridevi, B. Kalaiselvi, M. Balaji Singh, K. Vijaykumar


Objective: To evaluate the most common class of antimicrobial agents used in surgical prophylaxis. To evaluate the timing, dosage, route and duration of use of antimicrobial agents in surgical prophylaxis.

Methods: The study subjects were 214 patients who underwent general surgical procedures at Vinayaka Missions Kirupananda Variyar Medical College from July 2013 to June 2014. The use of antimicrobial agents was noted from the first dose of antibiotic given before the induction of anaesthesia. After surgery was completed the duration of antibiotic in the post-operative ward was noted.

Results: Majority of the patients were males of age group 50-60 y and the most common surgical procedure was hernioplasty. Combination therapy with two antimicrobial agents was more preferred regimen 126 (58.9%). Among the antimicrobial agent's cefotaxime 114 (24.8%) was the most commonly prescribed drug and it was followed by metronidazole 121 (21.9%). ceftriaxone 60 (13.1%) was the third most commonly prescribed antimicrobial agent. The mean duration of prescription of antimicrobial agents in the present study was 4.78 d and the mean cost of drug treatment was 787.54 rupees. The cost-effective regimen was that of aminoglycosides and imidazole.

Conclusion: The choice of antimicrobial agent was based on the local prevalence pattern of microorganisms. The intravenous administration of antibiotic prophylaxis immediately before or after the induction of anaesthesia is the most reliable method for ensuring effective serum concentration at the time of surgery. The antimicrobial agent chosen must cover all the most likely contaminating organisms.


Antimicrobial agents, Surgical prophylaxis

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Antimicrobial agents, Surgical prophylaxis





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International Journal of Pharmacy and Pharmaceutical Sciences
Vol 9, Issue 1, 2017 Page: 283-287

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Authors & Affiliations

C. S. Brethis
Dept Of Pharmacology ,ACS Medical College &Hospital, Chennai India

S. Thamizharasan
Dept Of Pharmacology ,ACS Medical College &Hospital, Chennai India

S. A. Sridevi
Dept Of Pharmacology ,ACS Medical College &Hospital, Chennai India

B. Kalaiselvi
Dept Of Pharmacology ,ACS Medical College &Hospital, Chennai India

M. Balaji Singh
Dept Of Forensic Medicine, ACS Medical College &Hospital, Chennai India

K. Vijaykumar
Dept Of Pharmacology , Mahavir Institute of Medical Sciences, Hydrebad India

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